Multidisciplinary colorectal oncology clinics bring together radiation oncologists, medical oncologists, and surgery teams to develop treatment programs that are more effective and efficient for patients. Drew Gunnells, Jr., MD; Rogeemon Jacob, MD; and Moh’d Khushman, MD, discuss the major breakthroughs informing multidisciplinary colorectal cancer care. More accurate staging, molecular profiling, and use of circulating tumor DNA to assess disease response are among the most significant advancements discussed. Meanwhile, the doctors note that COVID-19 protocols have highlighted the efficiency of using telehealth and exploring fewer radiation treatments when possible