TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful

TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) VITT-like disorder after adenovirus infection (NEJM) The clot thickens (TWiV 842) Lessons from VITT (Nat Rev Immunol) Pan-sarbecovirus neutralizing mAb (Sci Adv) Letters read on TWiV 1037 Timestamps by Jolene. Thanks! Weekly Picks

Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope
Brianne – Question Mark in Space?
Kathy – Quammen interview with Walter Isaacson
Rich – Chrome Music Lab
Vincent – Matters Microbial

Listener Picks

Tom – The (second) deadliest virus
Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III)
Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]