Data is changing healthcare. Health information systems deal with the entire pipeline of health related data from data capture/acquisition, information extraction, Data analytics and interpretation, presentation and decision support. We had the opportunity to talk with a distinguished guest Dr May D. Wang, Associate Professor at Georgia Institute of Technology and Emory University. In the first part Dr Wang gives an overview of the role of data in healthcare and some of the key challenges in adopting and exploiting the benefits of new information systems in healthcare. We talk about the increasing role of personal and personalized healthcare solutions, the stakeholder landscape and the importance of managing change in legacy healthcare environments and ecosystems. At the last part of this interview Dr. Wang talks about the extensive educational and training activities that are currently in progress: from online Master-level courses in bio-medical data analytics for young scientists to patient training and hospitals/physicians decision support systems. Interviewed by George Voulgaris for Tech Talks central.