The Myriad effect has taken over National City, and even Superman is under control, leaving Kara, Cat, and Maxwell as the only ones immune. Now Kara must find a way to stop Non but Maxwell is looking at destroying Kryptonians with a bomb at the risk of killing humans over Cat's objections, prompting Kara to find an alternative. The effect brings fugitives Alex and J'onn back but not before Alex telling Eliza the truth about what really happened to Jeremiah but leave out the part about Jeremiah being alive. When Indigo senses the two returning, she defeats J'onn but takes Alex, and places her under mind control as Non's payback for Astra's death.