TEL AVIV — In the worst flare-up of violence in seven years, Israel launched airstrikes and Palestinian militants launched hundreds of missiles overnight into Wednesday, killing more than 50 people and injuring hundreds more amid rising fears the conflict could spiral into all-out war.

What started as a week of tense clashes in Jerusalem has escalated into violent unrest on the streets of Arab Israeli towns, as well as a deadly aerial conflict — more than 1,000 rockets lit up the skies of Israeli cities, while at least two high-rise buildings were levelled in the Israeli bombardment of the blockaded and impoverished Gaza Strip, home to 2 million Palestinians.

At least 53 people, including 14 children, were killed in the Israeli bombardment, according to the Gaza Health Ministry.

Bassem Issa, the commander for Gaza City, was also among the dead, Hamas' military wing, the al-Qassam Brigades, confirmed. Staff Sgt. Omer Tabib of the Israel Defence Forces was also killed.

Five Israelis were killed in the coastal cities of Ashkelon and Rishon Lesion, and in the city of Lod southeast of Tel Aviv, officials said. In total, more than 200 people have been wounded in Israel, while there have been more than 300 Palestinians injured, according to authorities on both sides.

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