The 2021 fantasy football season continues with our must-have Week 6 waiver wire pickups and running backs to target! Anthony Aniano gives his in-depth fantasy football advice, breaking down some of his waiver wire adds to prioritize and free agent pickups for running backs as we head into Week 6 of the fantasy football season. There was a lot of action last week, players that emerged, and running backs that were injured including Saquon Barkley, Clyde Edwards-Helaire and Chris Carson - so it's the perfect time to look for replacements or additions to help improve your teams. These RBs should be targets as injury replacements, streamers, sleepers, and general waiver wire targets to improve your fantasy football teams.