Vancouver’s Downtown Eastside is amongst the most studied neighbourhood in the country. At any one time, there are dozens of research projects looking into the effects of drug use, poverty and other topics. Local residents donate a lot of time to assist researchers but often receive little or no benefit from their participation. Two local residents and a PhD student are among a group of people who have come up with a framework for ethical research in the Downtown Eastside. We speak with Samona Marsh, Nicolas Crier and Scott Neufeld.