Real Life Pharmacology - Pharmacology Education for Health Care Professionals artwork

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

320 episodes - English - Latest episode: 7 days ago - ★★★★★ - 626 ratings

A Meded101.com Production

Medicine Health & Fitness Education
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Episodes

Beers Criteria Podcast Part 1 or 2

March 21, 2024 15:43 - 19 minutes - 9.12 MB

In this podcast episode, I break down some of the most common medications that show up on the Beers criteria list. I discuss cardiovascular medications in this podcast episode, including rivaroxaban and warfarin, and why they show up on the Beers list. Alpha-blockers who up on the Beers list as these medications are inappropriate to use for the management of hypertension. The Beers criteria addresses the use of aspirin in primary prevention. I break down what the criteria state and why ...

Navigating QTc Prolongation and Drug Interactions

March 14, 2024 15:38 - 19 minutes - 8.77 MB

On this episode, I discuss the pharmacology surrounding QTc prolongation and drug interactions. I discuss which medications are more likely to cause QTc prolongation and which patient populations we should be more concerned about. Antiarrhythmics are a common class of medication that can exacerbate QTc prolongation when used with other interacting medications. 500 ms is a common value utilized to help identify patients at risk for QTc prolongation and ultimately torsades de pointes.

Risedronate Pharmacology Podcast

March 07, 2024 16:07 - 16 minutes - 7.78 MB

On this podcast episode, I cover risedronate pharmacology, adverse effects, drug interactions, and much more. There is a strict administration procedure with risedronate which is designed to reduce adverse effects and enhance absorption. I discuss this in the podcast. Many medications may cause osteoporosis and may precipitate treatment with risedronate. Corticosteroids and excessive thyroid hormone replacement are two examples. Patients should remain upright (sitting or standing) for a...

Antihypertensive Drug Interactions Podcast – Episode 316

February 29, 2024 16:38 - 13 minutes - 6.37 MB

On this podcast episode, I discuss some of the most common antihypertensive drug interactions you need to know. One major interaction I discuss is the trifecta of a diuretic, an ACE or ARB, and an NSAID. This combination significantly increases the risk for acute renal failure. Nitrates aren't classically referred to as an antihypertensive but they can definitely cause some problems when combined with PDE5 Inhibitors. Lithium can interact with 3 blood pressure medication classes. ACEIs,...

Teplizumab For Diabetes Episode 315 – Real Life Pharmacology Podcast

February 22, 2024 16:01 - 15 minutes - 14.3 MB

Teplizumab is a relatively new agent that helps delay the progression of type 1 diabetes. It slows the rate of beta-cell destruction in the pancreas. Teplizumab is associated with cytokine release syndrome which can result in flu-like symptoms of fever, aches, and headache. Cytokine release syndrome due to teplizumab can be reduced by using appropriate pretreatment medications. Those medications can include analgesics, antihistamines, and/or antiemetics. Teplizumab is associated with su...

Teplizumab For Diabetes – Real Life Pharmacology Podcast

February 22, 2024 16:01 - 15 minutes - 14.3 MB

Teplizumab is a relatively new agent that helps delay the progression of type 1 diabetes. It slows the rate of beta-cell destruction in the pancreas. Teplizumab is associated with cytokine release syndrome which can result in flu-like symptoms of fever, aches, and headache. Cytokine release syndrome due to teplizumab can be reduced by using appropriate pretreatment medications. Those medications can include analgesics, antihistamines, and/or antiemetics. Teplizumab is associated with su...

Captopril Pharmacology Podcast – Episode 314

February 15, 2024 15:23 - 14 minutes - 13.4 MB

On this podcast episode, I discuss captopril pharmacology, kinetics, interactions, and much more! Captopril is an ACE Inhibitor. It can cause hyperkalemia, cough, and renal impairment. One of the notable issues with captopril is its relatively short half-life which requires it to be dose frequently throughout the day. Lithium is an important drug interaction and the use of captopril with this medication may increase concentrations and the chance for toxicity.

Mechanisms of Drug Interactions Episode 313

February 08, 2024 16:57 - 19 minutes - 18.2 MB

On this episode of the Real Life Pharmacology podcast, I take a dive into the most common mechanisms of drug interactions. Below I list some of the common drug interactions seen in practice and how they work! Opposing Effects Many drugs will work on various receptors throughout the body. To use as an educational point, there is no better example to point to than the beta receptor. Beta-blockers are frequently used in clinical practice for their ability to lower blood pressure and slow the h...

Insulin Aspart (Novolog) Pharmacology Podcast Episode 312

February 01, 2024 15:39 - 14 minutes - 6.52 MB

On this podcast episode, I discuss insulin aspart pharmacology, adverse effects, drug interactions, and much more. Insulin apart is a rapid acting insulin product meant to bring down blood sugars quickly (most often after meals). It is important to remember a couple of medications that may counteract the effects of insulin and apart and raise blood sugar. I talk about corticosteroids and thiazide diuretics in the drug interaction section. Fiasp is a slightly modified insulin aspart mole...

Gentamicin Pharmacology Podcast Episode 311

January 25, 2024 16:18 - 14 minutes - 6.66 MB

On this podcast episode, I discuss gentamicin pharmacology, adverse effects, monitoring, drug interactions and much more! Drug monitoring is critical with gentamicin. Trough and peak concentrations can guide therapy and identify someone at risk of toxicity. Nephrotoxicity is a major concern with gentamicin. There are numerous nephrotoxic agents that can increase this risk. I discuss them on the podcast. Ototoxicity is another risk associated with gentamicin. Loop diuretics like furosemid...

Fenofibrate Pharmacology Podcast Episode 310

January 18, 2024 16:43 - 13 minutes - 12.2 MB

On this podcast episode, I discuss fenofibrate pharmacology, adverse effects, kinetics, drug interactions, and much more! Fenofibrate is typically only used for hypertriglyceridemia. The primary risk of hypertriglyceridemia is pancreatitis so we treat these levels because of this risk. LFTs elevation has been associated with fenofibrate use as well as myopathy. In the presence of myopathy, checking CPK may be considered. Fenofibrate is a weak CYP2C9 inhibitor. Warfarin and phenytoin are ...

Levofloxacin Pharmacology Podcast Episode 309

January 11, 2024 16:33 - 13 minutes - 6.13 MB

On this podcast episode, I discuss levofloxacin pharmacology, adverse effects, boxed warnings, interactions, and much more. Levofloxacin is well known to cause QTc prolongation and many drugs can increase this risk such as antiarrhythmics, citalopram, antipsychotics, and many more. Binding interactions are important when discussing levofloxacin pharmacology. Calcium, iron, magnesium, and many other cations can block the absorption of this medication. I discuss tendon rupture in relation...

Darifenacin Pharmacology Podcast – Episode 308

January 04, 2024 17:10 - 12 minutes - 5.78 MB

On this podcast episode, I discuss darifenacin pharmacology, adverse effects, drug interactions and much more. CYP3A4 and CYP2D6 are important enzymes in relation to darifenacin. I breakdown the importance of these enzymes and how they can impact drug therapy. Darifenacin has anticholinergic activity but affects the central nervous system less than other agents in its class such as oxybutynin and tolterodine. Darifenacin's pharmacology is selective for the Muscarinic-3 (M3) receptor in ...

Naltrexone Pharmacology Podcast – Episode 307

December 28, 2023 16:00 - 13 minutes - 12.2 MB

In this podcast episode, I discuss naltrexone pharmacology, adverse effects, drug interactions, and much more. Naltrexone is an opioid antagonist and can blunt the effects of opioid agonists. Because of this, the medication can be used to manage opioid use disorder. Hepatotoxicity is a concern of naltrexone and because of this, it is recommended to monitor LFTs. There is an injectable, long-acting formulation of naltrexone that can be used for opioid and alcohol use disorder treatment.

Acamprosate Pharmacology Podcast – Episode 306

December 21, 2023 15:52 - 11 minutes - 5.19 MB

On this podcast episode, I discuss acamprosate pharmacology, adverse effects, drug interactions, and much more! Acamprosate's most common adverse effect is diarrhea. It is a primary reason why patients will ask to stop taking this medication. It is critical to assess renal function prior to using acamprosate. Dose adjustments are recommended when patients have a CrCl of less than 50 ml/min. Unlike naltrexone, acamprosate avoids liver metabolism making it an alternative option in alcohol u...

Alfuzosin Pharmacology Podcast

December 14, 2023 16:26 - 13 minutes - 12.2 MB

On this podcast episode, I discuss alfuzosin pharmacology, adverse effects, drug interactions, and much more! Alfuzosin is an alpha blocker used to help relieve the symptoms of BPH. Low blood pressure is a possible adverse effect of alfuzosin and is more likely when combined with PDE-5 inhibitors like sildenafil. CYP3A4 is an important enzyme in the metabolism of alfuzosin. Inhibitors of CYP3A4 can raise concentrations and increase the chance of alfuzosin toxicity.

Methadone Pharmacology Podcast

December 07, 2023 16:38 - 16 minutes - 15.3 MB

In this podcast episode, I discuss methadone pharmacology, adverse effects, drug interactions, and pharmacokinetics. Methadone is a full opioid agonist that may be used for pain management and opioid use disorder. Transitioning from methadone to another opioid is complicated. I discuss conversion in this podcast episode. Methadone can increase the risk of QTc prolongation and also has a lot of drug interactions. I discuss them in detail in this podcast episode.

Meperidine Pharmacology Podcast

November 30, 2023 16:52 - 14 minutes - 12.9 MB

On this podcast episode, I discuss meperidine pharmacology, adverse effects, pharmacokinetics, drug interactions, and much more! Meperidine is an opioid that is seldom used due to neurotoxicity. I describe how this can happen in this podcast episode. Meperidine has numerous drug interactions and using a CYP3A4 inhibitor may increase the risk for toxicity. Seizures are a risk with meperidine due to its neurotoxic metabolite normeperidine. I discuss this further in this podcast episode.

Guanfacine Pharmacology Podcast

November 23, 2023 13:22 - 13 minutes - 12 MB

On this episode of the podcast, I cover guanfacine pharmacology, adverse effects, drug interactions, and much more. Guanfacine is a central acting alpha-2 agonist that has the brand names of Tenex and Intuniv. Because of guanfacine's mechanism of action, it suppresses the sympathetic response leading to a drop in pulse and blood pressure. It is important to remind patients that the onset of action is slow in the management of ADHD with guanfacine. I discuss this further in this podcast e...

Fluvastatin Pharmacolgy Podcast

November 16, 2023 16:49 - 12 minutes - 11.5 MB

On this podcast episode, I discuss fluvastatin pharmacology, adverse effects, pharmacokinetics, and much more. Fluvastatin is only a low to moderate-intensity statin which explains its limited use compared to rosuvastatin or atorvastatin. I discuss drug interactions in the podcast but one important one to recognize is drugs that can inhibit CYP2C9. Fluvastatin is considered a lipophilic statin. I have previously discussed this on the Meded101 blog which you can find here.

Oxymorphone Pharmacology Podcast

November 09, 2023 15:24 - 14 minutes - 13.1 MB

In this episode, I discuss oxymorphone pharmacology, adverse effects, drug interactions, and more! Oxymorphone is approximately 3 times more potent than morphine. I break down some common opioid comparisons in this episode. Oxymorphone avoids many of the CYP interactions. I discuss some of the common interactions in this episode. I discuss histamine release in relation to opioids and oxymorphone and specifically how this may impact our patients.

Diclofenac Pharmacology Podcast

November 02, 2023 15:11 - 13 minutes - 12.2 MB

On this podcast episode, I discuss diclofenac pharmacology, adverse effects, drug interactions, and much more. Diclofenac is one of the highest-risk NSAIDs when it comes to cardiovascular risk. You can find more information on this in the Meded101 NSAID comparison table. Diclofenac carries two boxed warnings. One is for GI bleed risk and the other is for cardiovascular risks. Anticoagulants, antiplatelets, diuretics, and ACEs/ARBs are all common medication classes that can interact with...

Aliskiren Pharmacology Podcast

October 26, 2023 14:53 - 11 minutes - 10.5 MB

On this episode, I discuss aliskiren pharmacology, adverse effects, drug interactions, and much more. Aliskiren should not be used with ACE Inhibitors or ARBs. I discuss why that is in this episode. Aliskiren has a long enough half-life at approximately 24 hours so it is recommended to only take this once daily. Hyperkalemia is a major concern with aliskiren. It is important to monitor potassium levels and renal function.

Buprenorphine/Naloxone Pharmacology Podcast

October 19, 2023 15:21 - 12 minutes - 5.51 MB

On this episode, I discuss the use of buprenorphine/naloxone in managing opioid use disorder. I cover the kinetics, dosage forms, adverse effect, interactions and much more. Buprenorphine/naloxone has numerous dosage form and they are not interchangeable. I discuss this further on the podcast. Liver impairment is a potential reason to avoid the use of buprenorphine. I discuss this on the podcast. You must keep an eye out for withdrawal symptoms when initiating and adjusting doses of bup...

Spironolactone Pharmacology Podcast

October 12, 2023 15:33 - 11 minutes - 5.46 MB

On this episode, I discuss spironolactone pharmacology, adverse effects, drug interactions and much more. Spironolactone has numerous indications including hypertension, CHF, ascites, and acne. I break them all down in this podcast episode. Hyperkalemia is a major concern with spironolactone. Patients with baseline levels at 5 or above should generally avoid this medication. Gynecomastia is one of the most commonly tested adverse effects of spironolactone. Be sure you don't miss this one...

Meloxicam Pharmacology Podcast

October 05, 2023 15:25 - 11 minutes - 10.8 MB

I discuss meloxicam pharmacology, adverse effects, drug interactions, and much more on this episode of the Real Life Pharmacology Podcast. Meloxicam tends to have a greater affinity to COX-2 versus COX-1. I discuss what this means clinically on this episode. Important meloxicam drug interactions include anticoagulants, antiplatelet medications, renal impairing drugs, and lithium amongst others. Meloxicam has a longer half-life than many NSAIDs and because of this can be dosed once daily...

Enalapril Pharmacology Podcast

September 28, 2023 14:47 - 13 minutes - 12.8 MB

On this episode, I discuss enalapril pharmacology, adverse effects, drug interactions, and much more! Enalapril has a shorter half-life compared to some of the other ACE inhibitors so it may need to be dosed twice daily in patients with adequate renal function. Hyperkalemia, cough, renal impairment, and angioedema and four adverse effects associated with enalapril that you should monitor for. NSAIDs and diuretics can increase the risk of acute renal failure when an ACE inhibitor like ena...

Asthma Pharmacotherapy Q&A With Beth Zerr, PharmD, BCACP

September 21, 2023 10:24 - 23 minutes - 21.3 MB

On this very special episode of the Real Life Pharmacology podcast, we tackle asthma pharmacotherapy and some of the things that Beth sees in her everyday practice as an ambulatory care pharmacist. When discussing asthma pharmacotherapy with pediatric patients and their families, it is critical to address the concern of suppressed growth with corticosteroid use. Beth shares her expertise and thoughts on this topic. The GINA update a few years ago has been a game changer in asthma, hear fr...

Lisdexamfetamine Pharmacology Podcast

September 14, 2023 13:13 - 11 minutes - 5.12 MB

On this podcast episode, I discuss lisdexamfetamine (Vyvanse) pharmacology, adverse effects, drug interactions, and much more. Lisdexamfetamine is a stimulant medication that is used in the management of ADHD. Stimulants like lisdexamfetamine can increase heart rate, raise blood pressure, and suppress appetite. Lisdexamfetamine is a schedule 2 controlled substance and has a high potential for abuse and dependence.

Etanercept Pharmacology Podcast

September 07, 2023 15:34 - 13 minutes - 6.23 MB

On this podcast episode, I cover etanercept pharmacology, adverse effects, drug interactions and much more. Etanercept is classified as a DMARD but is different from older DMARDs in that it is a biologic agent and needs to be injected. Vaccination assessment in patients is important prior to initiating etanercept due to the fact that the medication may blunt the effectiveness of the vaccines. Immunosuppression from etanercept can lead to an increased risk for infection and malignancy.

Insulin Lispro (Humalog) Pharmacology Podcast

August 31, 2023 15:30 - 18 minutes - 8.25 MB

On this podcast episode, I discuss the pharmacology, adverse effects, and drug interactions of insulin lispro (Humalog). I spend some time on this podcast episode discussing carb ratios and sliding scale insulin when using insulin lispro. Potassium is critical to monitor in diabetic ketoacidosis as insulin therapy can cause significant hypokalemia. Sliding-scale insulin lispro is discouraged in the overwhelming majority of situations. Ideally, we should be more proactive about insulin ad...

Pregabalin Pharmacology Podcast

August 24, 2023 12:17 - 15 minutes - 14.3 MB

On this podcast episode, I discuss (Lyrica) pregabalin pharmacology, adverse effects, drug interactions, and much more. I compare pregabalin and gabapentin in this episode and one important difference is the percent absorption of gabapentin compared to pregabalin. Pregabalin can exacerbate the risk of respiratory depression and overdose in patients who are taking opioids. Pregabalin is most frequently used in practice for neuropathic pain syndromes.

Tamoxifen Pharmacology Podcast

August 17, 2023 15:58 - 14 minutes - 13.7 MB

On this podcast episode, I discuss tamoxifen pharmacology, adverse effects, drug interaction, and much more. Tamoxifen is converted to a more active compound in the body by CYP2D6. CYP2D6 inhibitors such as paroxetine, fluoxetine, or bupropion can essentially reduce the effectiveness of tamoxifen. Hot flashes are a common adverse effect of tamoxifen and I discuss a few pharmacologic options to manage this adverse effect.

Phenobarbital Pharmacology Podcast

August 10, 2023 15:31 - 14 minutes - 6.79 MB

On this episode of the Real Life Pharmacology Podcast, I cover phenobarbital pharmacology, adverse effects, important drug interactions and much more. Phenobarbital is an enzyme inducer. It is an inducer at CYP3A4 so this can lead to numerous drug interactions. Phenobarbital can exacerbate the risk for opioid overdose and increase the risk for respiratory depression and death. Phenobarbital can deplete numerous vitamins such as vitamin D, folic acid, and vitamin B12. Monitoring of these ...

Isotretinoin Pharmacology Podcast

August 03, 2023 15:32 - 11 minutes - 10.7 MB

On this episode, I discuss isotretinoin pharmacology, side effects, drug interactions, and much more. The iPLEDGE program is in place to ensure that pregnant patients do not receive this medication. I discuss this in more detail on this episode. Sun sensitivity is an important adverse effect that patients should be aware of during seasons of high sun exposure. Hepatic issues, myalgia, and psychiatric changes are rare adverse effects associated with isotretinoin.

Lovastatin Pharmacology Podcast

July 27, 2023 15:33 - 14 minutes - 13.5 MB

On this episode of the Real Life Pharmacology Podcast, I discuss lovastatin pharmacology, adverse effect, drug interactions, and more! Lovastatin is broken down by CYP3A4 so drugs like clarithromycin, diltiazem, and others may increase concentrations. Lovastatin is a lipophilic statin and I discuss the importance of this on the podcast. Lovastatin has a very short half-life which means that it is ideal to dose this medication at night for maximal efficacy.

Clindamycin Pharmacology Podcast

July 20, 2023 15:23 - 11 minutes - 10.8 MB

On this podcast episode, I discuss clindamycin pharmacology, adverse effects, drug interactions, and much more! Clindamycin (oral administration) can cause esophageal irritation and it is recommended to take this medication with a full glass of water. C. Diff risk and frequent dosing are two of the biggest downsides to using clindamycin to manage infections. Clindamycin has good activity against many gram-positive organisms like Staph and Strep as well as anaerobic activity.

Dextroamphetamine Pharmacology Podcast

July 13, 2023 15:26 - 12 minutes - 5.93 MB

On this podcast episode, I discuss dextroamphetamine's pharmacology, adverse effects, drug interactions, and much more! Dextroamphetamine is a stimulant medication. Weight loss, insomnia, tachycardia, and hypertension are all possible complications. There is a patch dosage form of dextroamphetamine available called Xelstrym. I discuss it on this episode. Vitamin C can reduce GI absorption of dextroamphetamine due to its ability to increase the acidity of the GI tract.

Vardenafil Pharmacology Podcast

July 06, 2023 15:14 - 11 minutes - 10.4 MB

On this podcast episode, I discuss vardenafil pharmacology, adverse effects, drug interactions, and much more. Vardenafil is a PDE-5 inhibitor used primarily for erectile dysfunction in males. Using nitrates with vardenafil is contraindicated due to the risk of profound hypotension. I have discussed how long to wait between vardenafil and nitrates in a previous post on Meded101.com.

Niacin Pharmacology Podcast

June 29, 2023 15:02 - 13 minutes - 6.2 MB

On this podcast episode, I discuss niacin pharmacology, adverse effects, drug interactions, and much more. Niacin has historically been used to manage lipids but has fallen out of favor due to adverse effects, and newer, more effective therapies being developed. Niacin can elevate uric acid. Be sure to use this medication cautiously in patients with gout. Flushing is one of the most common adverse effects of niacin. High doses, immediate-release formulations, and the use of alcohol can i...

Dextromethorphan Pharmacology Podcast

June 22, 2023 14:03 - 15 minutes - 13.9 MB

I discuss dextromethorphan pharmacology, adverse effects, drug interactions, and more on this podcast episode. CYP2D6 metabolizes Dextromethorphan. A commonly used antidepressant is a CYP2D6 inhibitor. I discuss this on the podcast. Dextromethorphan is a commonly used OTC cough suppressant. There is potential for abuse with this medication. In excessive doses, dextromethorphan may cause euphoria, hallucinations, and other CNS effects, but also cause cardiovascular complications.

Bexagliflozin Pharmacology Podcast

June 15, 2023 15:41 - 13 minutes - 12.3 MB

On this podcast episode, I discuss bexagliflozin pharmacology, adverse effects, drug interactions, and much more. I wasn't wowed by the A1C reduction of this medication. I get into the specifics on bexagliflozin in the podcast episode. SGLT2 inhibitors like bexagliflozin increase the glucose in the urine which can facilitate the growth of bacteria and fungi in the genitourinary tract. Limb amputation and euglycemic DKA are two rare, reported adverse effects to be aware of with the use o...

Cefuroxime Pharmacology Podcast

June 08, 2023 15:50 - 13 minutes - 12.4 MB

On this episode, I discuss cefuroxime pharmacology, adverse effects, drug interaction, pharmacokinetics, and much more. Cefuroxime is a 2nd generation cephalosporin that binds Penicillin-binding proteins and prevents bacterial cell wall synthesis. Medications that create a higher pH in the stomach such as antacids can ultimately reduce the concentrations of cefuroxime. Cefuroxime is primarily eliminated by the kidney. Dose adjustments are recommended for patients with a CrCL less than 3...

Risperidone Pharmacology Podcast

June 01, 2023 15:27 - 14 minutes - 6.75 MB

On this episode, I discuss risperidone pharmacology, adverse effects, monitoring, and common indications. There are numerous drug interactions that I discuss in this podcast episode. CYP2D6 inhibitors may increase drug concentrations. Risperidone increases prolactin more than most 2nd generation antipsychotics. This can lead to sexual adverse effects. QTC prolongation is a concern with all antipsychotics like risperidone. We can monitor EKG to monitor for this risk.

Vortioxetine Pharmacology Podcast

May 25, 2023 14:40 - 15 minutes - 7.22 MB

On this podcast episode, I discuss vortioxetine pharmacology, adverse effects, drug interactions, and much more. Because of vortioxetine's long half-life, antidepressant discontinuation syndrome is going to be less prominent compared to ADPs with shorter half-lives. Vortioxetine is metabolized by CYP2D6. Drugs that inhibit this enzyme will likely raise concentrations and place the patient more at risk for adverse effects. I discuss rare vortioxetine adverse effects like hyponatremia and ...

Isosorbide Mononitrate Pharmacology Podcast

May 18, 2023 15:04 - 12 minutes - 5.64 MB

On this episode, I discuss isosorbide mononitrate pharmacology, adverse effects, and important drug interactions. Isosorbide mononitrate is a vasodilator that works by relaxing and widening the blood vessels (primarily veins) through nitric oxide action. This reduces the preload and oxygen demand on the heart. The primary use for isosorbide mononitrate is angina prevention. It is important to remember that it is NOT meant for acute relief of chest pain. Headache is a major adverse effect ...

Azelastine Nasal Spray Pharmacology Podcast

May 11, 2023 15:25 - 13 minutes - 6.31 MB

On this episode of the RLP podcast, I discuss azelastine nasal spray pharmacology, adverse effects, administration, and much more! While most nasal sprays for allergic rhinitis are corticosteroids, azelastine is classified as an antihistamine. Systemic absorption of azelastine is about 40%, so while not common, systemic adverse effects like sedation can happen. On this podcast episode, I use azelastine to remind you about important education points regarding the use of nasal sprays.

Amlodipine Pharmacology Podcast

May 04, 2023 15:49 - 18 minutes - 17 MB

On this episode of the Real Life Pharmacology Podcast, I discuss amlodipine pharmacology, adverse effects, and important drug interactions. I break down why edema occurs with amlodipine on this episode of the Real Life Pharmacology podcast. While beta-blockers are typically the first-line agent for the prevention of chronic angina symptoms, CCBs like amlodipine can be used as an alternative. There are some potential CYP3A4 interactions with amlodipine. I discuss the severity of these in...

Pyridoxine Pharmacology

April 28, 2023 03:26 - 12 minutes - 5.65 MB

On this episode, I discuss pyridoxine pharmacology, adverse effects, and important clinical uses. Pyridoxine is most well known for its potential to reduce the likelihood of isoniazid-induced neuropathy. Another common indication of pyridoxine is its use for nausea and vomiting associated with pregnancy. Pyridoxine plays an important role in the production of heme, so deficiency will increase the risk for anemia.

Vibegron Pharmacology Podcast

April 20, 2023 14:16 - 12 minutes - 11.6 MB

On this episode of the Real Life Pharmacology podcast, I discuss vibegron pharmacology, adverse effects, drug interactions and more! I spend some time comparing and contrasting vibegron to mirabegron. Both are beta-3 agonists used for overactive bladder. Vibegron dosing is very simple. It is dosed once daily with no alternative dosage forms available. The starting dose is the target dose. Being primarily excreted in the feces and urine, vibegron doesn't have many drug interactions.