EMPA-REG OUTCOME back in 2015 this was the first SGLT2 trial to set the world on fire with Primary Outcome: 

death from cardiovascular causes: NNT 46 per 3.1 yrs (at $600 a month, 1 million dollars per life saved)

nonfatal myocardial infarction: NS∞

nonfatal stroke: NS∞





https://www.nejm.org/doi/full/10.1056/nejmoa1504720