PubReading [28] - DNA G‐quadruplexes in the human genome: detection, functions and therapeutic potential - R. Hänsel-Hertsch, M. Di Antonio and S. Balasubramanian
PubReading
English - October 04, 2021 20:00 - 32 minutes - 59.7 MBLife Sciences Science Health & Fitness Medicine Homepage Download Apple Podcasts Google Podcasts Overcast Castro Pocket Casts RSS feed
Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy. - doi:10.1038/nrm.2017.3 - 2017