Fifty years ago, on 25th April 1953, there appeared three papers in the journal, Nature, which changed our view of the world. The structure of the DNA double helix, with its complementary base-pairing, is one of the greatest discoveries in biology in the 20th Century. It was also most dramatic, since, quite unexpectedly, the structure itself pointed to the way in which a DNA molecule might replicate itself, and hence revealed the “secret of life”. The structure was solved in the Cavendish Laboratory, Cambridge by Francis Crick and James Watson, using X-ray diffraction data from fibres of DNA obtained by Rosalind Franklin at King’s College, London.

doi:10.1016/j.jmb.2003.11.015 - 2004