PubReading [142] - Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology - S. Epple, A. El-Sagheer and T. Brown
PubReading
English - June 09, 2022 20:00 - 13 minutes - 24 MBLife Sciences Science Health & Fitness Medicine Homepage Download Apple Podcasts Google Podcasts Overcast Castro Pocket Casts RSS feed
The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported arti- ficial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleo- tides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.
doi.org/10.1042/ETLS20210169 - 2021