In this Professor Jimbles' Dice Bag, Paul, Stephen, Adam, David and Jimbles talk about creating your Homebrew settings, and how they interact with mechanical systems!

Stephen's Mary Sue Game Adventure Logs: https://soyouwanttobeamarysue.obsidianportal.com/

Pathfinder: https://en.wikipedia.org/wiki/Pathfinder_Roleplaying_Game ,
Dungeons and Dragons Editions: https://en.wikipedia.org/wiki/Editions_of_Dungeons_%26_Dragons,
GURPS: www.sjgames.com/gurps/,
Warhammer Fantasy: https://www.fantasyflightgames.com/en/products/warhammer-fantasy-roleplay/,
Shadowrun: http://www.shadowruntabletop.com/ ,
Fantasy Flight Star Wars: https://www.fantasyflightgames.com/en/products/star-wars-edge-of-the-empire/ ,
Mongoose Traveller: www.mongoosepublishing.com/rpgs/traveller.html Starfinder: https://paizo.com/starfinder/ ,
Rogue Trader: https://www.fantasyflightgames.com/en/products/rogue-trader/
FATE: www.evilhat.com/home/fate-core/
Savage Worlds: https://www.peginc.com/product-category/savage-worlds/
And we talk about Fate Zero for way too long: https://en.wikipedia.org/wiki/Fate/Zero