Episode 17: On-demand Control of Endogenous Genes

This week we discuss an amazing new technique developed by Dr Jakub Gemperle (@GemperleJakub), a Marie Curie Postdoctoral Research Fellow at the University of Manchester (@OfficialUoM). This technique uses 3 different inducible systems to allow on-demand control of endogenous genes, including being able to remove genes and then re-express them. A nice all in one package of techniques, great for rescue experiments!! We then also talk about Magnetogenetics where cells (and vesicles) can be moved around via magnets! As always we ask how this person found preprinting and we delve into the wonderful idea of permanent postdocs.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.12.03.471086v1.full

Other links

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001285

First Pig to Human heart transplant

https://www.nature.com/articles/d41586-022-00111-9

This episode was produced by Emma Wilson and edited by John D Howard.

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