#276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more

Drive with Dr. Peter Attia

Key Takeaways The truth behind longevity research: there’s no evidence to think we’ll live to 120+ years old – this should motivate us to move the needle to take action to improve our healthspan
It’s better to live 90 healthy years than 120 years but the poor quality of life the last 20“What I think people should fixate on is how do I not be really, really frail both physically and cognitively in the last decade of my life.” – Dr. Peter AttiaWe have control over whether we can stay physically active, move under our own power, etc.Take Peter’s supplement list with a grain of salt – you might not need the same things he takes; ideally, get your bloodwork done regularlyA very low carbohydrate, low saturated fat diet would lower apoB but not to levels that would make ASCVD irrelevant; it’s also probably not a sustainable diet“The most important parameter for determining metabolic health is energy balance. Even the most ‘perfect’ diet, if it’s in excess of energy balance will produce poor metabolic health.” – Dr. Peter AttiaThe most important factor in diet & nutrition is what you can sustain

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In this special episode of The Drive, Peter discusses a variety of topics, breaking away from the typical deep-dive format to explore a wide range of common questions submitted by listeners. Peter tackles subjects like the viability of living to 120 and beyond, addressing some of the optimistic theories regarding achievement of this remarkable feat. Peter then shares his drug and supplement regimen while emphasizing how individualized these protocols need to be. The conversation also touches on lowering apoB, the long-term use of statins, the myth of good vs. bad cholesterol, the complexities of nutrition research, the quest for the ideal diet, and Peter's strategies for hitting daily protein goals. Peter finishes with a discussion about his favorite health-tracking wearables, the role of CGM in non-diabetics, and more.

We discuss:

Overview of topics and previous episodes of a similar format [2:45]; The viability of living to 120 and beyond: some optimistic theories [4:45]; The potential of mTOR inhibition as a mid-life intervention, and longevity potential for the next generation [13:30]; A framework for thinking about geroprotective drugs and supplements in the context of a lack of aging biomarkers [17:00]; Supplements Peter takes and how his regimen has changed in the last year [26:15]; Pharmacologic strategies to lower ASCVD risk, the limitations of statins, nutritional interventions, and more [36:15]; Misnomers about cholesterol [48:00]; Why nutritional research is so challenging, some general principles of nutrition, and why Peter stopped doing prolonged fasts [50:45]; Optimizing protein intake [59:45]; Wearables for sleep and exercise, continuous glucose monitors (CGM), and a continuous blood pressure monitor on the horizon [1:04:45]; and More.

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