This week’s episode explores the sedative and anxiolytic agent dexmedetomidine and its use in the pediatric cardiac ICU. This agent, which was initially introduced for short term sedation, is increasingly used in our postoperative cardiac patients and we explore issues related to its use with particular attention to the issue of withdrawal. Dr. Michael Ushay, Director of Pediatric Critical Care at The Children’s Hospital at Montefiore joins us to provide clinical insight and perspective.