Featuring articles on a trial of an antibody to amyloid in Alzheimer’s disease, short-course treatment of tuberculosis, weight loss maintenance with exercise and liraglutide, dexamethasone and surgical-site infection, a fountain of youthful retinal ganglion cells, and decoupling crisis response from policing; a review article on gastric emptying abnormalities in diabetes; a Clinical Problem-Solving on the inside and out; and Perspective articles on understanding and mitigating health inequities, on designing an independent public health agency, and on losing touch.