Building Stronger Hearts: Arteriogenesis, Angiogenesis, and the Path to Cardiovascular Wellness

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In today's episode:

Raising your CRF score, which reflects your body's ability to utilize oxygen during exercise, triggers several molecular and physiological adaptations that contribute to the formation of new blood vessels (angiogenesis) and the remodeling of existing arteries (arteriogenesis). Here's how these processes occur and contribute to lowering your clinical risk of cardiovascular disease:

Increased Oxygen Demand: When you engage in physical activity, your muscles require more oxygen to meet the increased energy demands. This elevated oxygen demand stimulates the release of signaling molecules such as vascular endothelial growth factor (VEGF) and nitric oxide (NO) within the vascular endothelium.
Stimulation of Angiogenesis: VEGF is a key factor in promoting the growth of new blood vessels (angiogenesis) from pre-existing ones. This process helps to expand the network of blood vessels, improving oxygen delivery to tissues and organs. Enhanced angiogenesis ensures adequate blood supply to active tissues, reducing the risk of ischemia and promoting tissue repair and regeneration.
Promotion of Arteriogenesis: Nitric oxide (NO), produced by endothelial cells in response to increased blood flow and shear stress, plays a crucial role in arteriogenesis.

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