This episode discusses four MMWR reports. First, despite very low risk of getting malaria in the U.S., locally acquired malaria cases reported in Florida and Texas highlight importance of quick diagnosis, treatment, and malaria prevention methods. Second, more than 33 million children in Africa are missing a measles vaccine, highlighting the urgent need to increase immunization efforts to prevent outbreaks and deaths. Third, the JYNNEOS vaccine offers protection against hospitalization among people with mpox, including people with HIV. Finally, norovirus was the main cause of illness among more than two dozen hikers on Washington's Pacific Crest Trail.