Mastering Nutrition
875 episodes - English - Latest episode: 4 months ago - ★★★★★ - 405 ratingsHi, I'm Chris Masterjohn and I have a PhD in Nutritional Sciences. I am an entrepreneur in all things fitness, health, and nutrition. In this show I combine my scientific expertise with my out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey to vibrant health. This show will allow you to master the science of nutrition and apply it to your own life like a pro.
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Episodes
Is Whole Food Vitamin C Really Different? | Masterjohn Q&A Files #330
December 18, 2023 14:00 - 23 minutes - 43.5 MBQuestion: Is whole food vitamin C superior to natural because it is part of a tyrosinase complex? Short Answer: Vitamin C is nearly ubiquitously distributed in plant tissues, and is never bound to any enzyme as a structural complex. Vitamin C promotes absorption of iron from plant foods, inhibits copper absorption, and de-loads copper from ceruloplasmin, which may play a role in distributing copper to tissues. Vitamin C is not capable of destroying ceruloplasmin. These functions follow dir...
What's the Deal With Seed Oils? | Masterjohn Q&A Files #329
December 04, 2023 14:00 - 30 minutes - 56.1 MBQuestion: What Is the Real Issue With Seed Oils? Short Answer: The main issue with seed oils is that they present an oxidative liability. They do not acutely cause oxidative stress, but their polyunsaturated fatty acids (PUFAs) are more vulnerable than any other macronutrient to oxidative damage. Oxidative stress can increase because of nutrient deficiencies, toxins, infections, other sources of inflammation, alcohol, or smoking, and it will inevitably increase as a function of aging. As ...
Is Hair Mineral Testing Useful? | Masterjohn Q&A Files #328
November 20, 2023 14:00 - 24 minutes - 45.3 MBQuestion: How useful is hair trace mineral analysis (HTMA) for nutritional testing? Short Answer: Hair trace mineral analysis is included as an optional add-on in the comprehensive nutritional screening from Testing Nutritional Status: The Ultimate Cheat Sheet, because it can capture data for some ultra-trace minerals for which there are no better-validated tests, and it might capture a pattern that might not be picked up as quickly with blood work, such as a mineral transport issue. Howev...
Secrets to Superior Cognitive Performance (Without Drugs)
November 17, 2023 18:23 - 51 minutes - 117 MBNutrition is far more powerful than drugs to improve cognitive performance. We start by looking at cocaine, Adderall, and Ritalin, and show why these drugs cannot possibly hold a candle to nutrition. Optimal nutrition can definitely optimize the function of dopamine, norepinephrine, acetylcholine, histamine, creatine, and the methylation system, and in doing so can simultaneously optimize focus, motivation, sustained attention, and mental flexibility, and methylation, all while eliminati...
Vitamin C, Whole Food Vs. Synthetic: Does It Matter?
November 16, 2023 18:39 - 7 minutes - 16.6 MBDebunking the myth that vitamin C in plants is found in a special "tyrosinase complex." For the written article with references, see here: https://chrismasterjohnphd.substack.com/p/vitamin-c-whole-food-vs-synthetic For issues of vitamin C dosing and balancing with other nutrients, see these two links: https://chrismasterjohnphd.substack.com/p/the-powerful-duo-how-glutathione https://chrismasterjohnphd.substack.com/p/balancing-vitamin-c-and-glutathione-d6f
Fact-Checking Gary Brecka on Rogan: A Deep Dive into MTHFR and Methylation
November 14, 2023 23:03 - 6 minutes - 8.3 MBWatch or listen to the full critique here: https://www.youtube.com/watch?v=kMPvCiOkEtQ
Cancer, IV Drips, and the Glutathione Vitamin C Connection
November 06, 2023 19:01 - 2 minutes - 2.96 MBIs high-dose vitamin C good for you? High-dose intravenous vitamin C can selectively kill cancer cells in live patients and can save sepsis patients from dying, but it acts as a pro-oxidant in cancer and an antioxidant in sepsis. So what does it do in the rest of us? Oral doses of 2000 milligrams raise oxalate levels in most people, and as little as 400 milligrams raises oxalate in some people. This seems to be the most sensitive indicator of a delicate imbalance with...
How to Find the Root Cause of Autoimmunity? | Masterjohn Q&A Files #327
November 06, 2023 14:00 - 20 minutes - 38.4 MBQuestion: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy met...
The Powerful Duo: How Glutathione and Vitamin C IV Drips Impact Cancer
November 01, 2023 14:03 - 32 seconds - 737 KBHigh-dose intravenous (IV) vitamin C has the potential to kill cancer cells and prolong the survival of terminal cancer patients. This podcast is a preview, the full video is available only to Masterpass members. See the written article with links to references here: https://chrismasterjohnphd.substack.com/p/the-powerful-duo-how-glutathione Subscribe to the Masterpass here: https://chrismasterjohnphd.substack.com/subscribe I am not a medical doctor and this is not medical advice. P...
Startled?! Try Glycine!
October 28, 2023 13:00 - 12 minutes - 29.4 MBThe ability to become startled is an adaptive behavior that protects us from being injured by a sudden threat, and prepares us for the fight-or-flight response when necessary. Nevertheless, getting startled too easily can be a sign that something is wrong. Here's what to do about it. For the written version with links to references and links to testing, see here: https://chrismasterjohnphd.substack.com/p/startled-try-glycine
Hormones Are Never In Charge
October 27, 2023 17:59 - 21 minutes - 50 MBHormones matter, but they are never in charge. Their abnormalities are never the root cause of anything. All hormones do is communicate the biochemistry of one tissue to the biochemistry of another tissue. In this episode: Three Reasons For Hormones to Be Messed Up Exceptions to the Rule Leptin, Insulin, and Thyroid Hormone As an Example How to Approach Hormones For the written version, the links to references, and the links to testing, see here: https://chrismasterjohnphd.sub...
Biotin’s Health Benefits: Way Beyond Hair and Nails
October 26, 2023 15:11 - 7 minutes - 16.1 MBMost people who take biotin take it for their hair and nails. Yet biotin does much more than this. Learn what to use it for, how much to take, and how to avoid adverse effects in less than ten minutes. Read the written and fully referenced version here: https://chrismasterjohnphd.substack.com/p/biotins-health-benefits-way-beyond Get my short and sweet tips on each nutrient in the Cliff Notes here: https://chris-masterjohn-phd.myshopify.com/products/the-vitamins-and-minerals-101-cl...
Exposing Harmful Supplements: Biotin's Dark Side
October 24, 2023 02:13 - 14 minutes - 32.6 MBThis is how to use a simple home measurement to expose the harmful effects of a supplement before they even happen. Read the article here: https://chrismasterjohnphd.substack.com/p/the-dark-side-of-biotin Subscribe to my newsletter to get my series on improving respiratory chain function as soon as new articles come out: https://chrismasterjohnphd.substack.com/subscribe See the "super unlock" article here: https://chrismasterjohnphd.substack.com/p/unlocking-performance-and-longevity
Why Would Vitamin C cause muscle pain, joint pain, and brain fog? | Masterjohn Q&A Files #326
October 23, 2023 14:00 - 27 minutes - 51.6 MBQuestion: Why Would Vitamin C cause muscle pain, joint pain, and brain fog? Short Answer: Acutely, vitamin C would likely cause these effects by generating oxalate, which could cause crystals that lead to muscle and joint pain, and could cut energy metabolism in half, leading to brain fog. This vulnerability could result from deficiencies of any of the B vitamins, any of the electrolytes, or of iron, copper, or sulfur; from diabetes, low adrenals, or hypothyroidism; or from any of the hun...
Why You Need THIS Supplement On a High-Protein Diet: Game-Changing Effects Explained by a PhD
October 18, 2023 00:32 - 5 minutes - 8.03 MBIf you are eating a high-protein diet, you probably aren’t getting enough biotin. This is especially true if you are a protein-fueled athlete and find your skin too oily, too itchy, or too red; if your blood sugar is getting out of control; or if you simply feel down in the dumps. And it’s especially true if you find your hands or feet tingling or get subtle sensations of something crawling on your skin. Alternatively, if you’re pregnant or looking to conceive, this is something you real...
Why High-Dose Biotin Could be the Answer for Your Blood Sugar, Brains, and Beauty
October 18, 2023 00:24 - 3 minutes - 4.94 MBThe use of high-dose biotin supplements has increased almost 30-fold over the last twenty years for such problems as diabetes, smell and taste disorders, disorders of the hair, skin, and nails, and multiple sclerosis. Studies show it can improve diabetes, and case reports show it can miraculously recover lost smell and taste even when smell and taste were lost as a result of surgery or the side effects of medications or other supplements. Yet, some studies show multiple sclerosis gets wo...
A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn’t, Analyze
October 13, 2023 16:34 - 4 minutes - 6.47 MBThe most useful tests are the ones no one ever orders. This podcast is available for free for 48 hours, and then will only be available to Masterpass members. The written and fully referenced article, the podcast, and the permanently available video can be found here: https://chrismasterjohnphd.substack.com/p/how-to-interpret-ketone-ratios-and
Can NAC hurt your gut health? | Masterjohn Q&A Files #325
October 09, 2023 14:00 - 41 minutes - 76.9 MBQuestion: Can NAC hurt your gut health? Short Answer: N-acetylcysteine or NAC can be used at a dose of 600 to 2,400 milligrams per day for 5-10 days to disrupt biofilms and make it easier for antimicrobials to kill bacteria. Animal studies suggest that acute doses up to 6 grams do not deplete mucus or cause ulceration, but that an acute dose of 17.5 grams can deplete mucus and cause ulcers within two hours. Human studies suggest that 10 grams per day can be used for 24 weeks with fewer th...
How I Found My Health “Super Unlock” After 20 Years of Research and 20,000 Genes Tested
October 08, 2023 13:13 - 15 minutes - 21.6 MBEach person has one to six highly unique unlocks that will only work for them, and this is how to find them. This podcast is only available here for the next 48 hours. This video is a free preview of a full-length 69-minute podcast. You can access the full video, full podcast, and the written and fully referenced article here: https://chrismasterjohnphd.substack.com/p/unlocking-performance-and-longevity
How can I protect against oxalates? | Masterjohn Q&A Files #324
September 25, 2023 14:00 - 4 minutes - 8.48 MBQuestion: How can I protect against oxalates? Short Answer: Getting 300-400 mg calcium between food and supplements at each meal will minimize oxalate absorption. Maintaining postprandial urine pH in the 6.4-6.8 range by getting 3-5 grams of potassium per day from food or from organic acid salts such as potassium citrate will prevent its crystallization in the kidney. Reducing dietary oxalate will prevent any possible damage in the gut. This is a clip from a live Q&A session open to CMJ...
Why Should Postprandial Glucose Be Kept Under 140 mg/dL? | Masterjohn Q&A Files #323
September 11, 2023 14:00 - 10 minutes - 19.2 MBQuestion: Why should postprandial blood glucose be kept under 140 milligrams per deciliter? Short Answer: When blood glucose rises above 140 mg/dL, this is the approximate point at which it spills into the polyol pathway at a greater-than-normal rate, which represents a suboptimal state of metabolism that is likely to hurt antioxidant status and compromise detoxification pathways as well as the recycling of vitamin K and folate. It must be kept in mind that a healthy person will adapt to ...
Methylene Blue in 10 Minutes
September 02, 2023 11:32 - 9 minutes - 22.8 MBWatch the full-length video here: https://www.youtube.com/watch?v=XhgGGbdw4zE&t=8621s Get my free 51--page report, Methylene Blue: Biohacker's Delight or Playing With Fire?, here: https://chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue
Methylene Blue: Biohacker's Delight, or Playing With Fire?
September 01, 2023 11:29 - 1 hour - 179 MBGet the written and referenced version here: https://chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue This is a 51-page guide in which you will learn the following: The Origin of Methylene Blue The Entry of Methylene Blue Into Medicine From Malaria to Many Uses in Medicine How Methylene Blue Works A Redox-Reactive Dye The Blue Bottle Experiment Methylene Blue Radicals, Photoexcited States, and Demethylated Metabolites Methylene Blue Can Oxidize and Reduce Ma...
What is the relationship between copper and estrogen? | Masterjohn Q&A Files #322
August 28, 2023 14:00 - 12 minutes - 22.7 MBQuestion: What is the relationship between copper and estrogen? Short Answer: Estrogen moves copper from the mother’s bloodstream to the fetus during pregnancy. Its action at the intestines is poorly understood but I believe estrogen and progesterone interact to promote intestinal copper absorption. Maintaining pregnancy-level hormones while not pregnant poses a risk of promoting too much absorption of copper from food without transferring it to a growing baby. Copper status should be moni...
Why Would Citrate or Malate Cause Insomnia?
August 23, 2023 00:40 - 31 minutes - 71.1 MBThis is now subscribers-only and is available here: https://chrismasterjohnphd.substack.com/p/why-would-citrate-or-malate-cause
What to Do About Constipation
August 22, 2023 23:01 - 41 minutes - 95.8 MBThis is now subscribers-only and can be accessed here: https://chrismasterjohnphd.substack.com/p/what-to-do-about-constipation
How to slow or reverse graying of hair? | Masterjohn Q&A Files #321
August 14, 2023 14:00 - 22 minutes - 41.9 MBQuestion: How to slow graying of hairs and potentially reverse it? Short Answer: What works for any given individual will likely be to find the weakest link and fix it, from among the following systems: the signaling of energy abundance (body fat, insulin sensitivity, thyroid hormone, adequate protein, individualized meeting of carbohydrate needs, good management of psychosocial stress, supporting neuroendocrine signaling with copper, vitamin C, zinc, and glycine, and supporting thyroid fu...
How Much Iron Can We Absorb At Once? | Masterjohn Q&A Files #320
July 31, 2023 14:00 - 28 minutes - 53.2 MBQuestion: How much iron can we absorb at once? Short Answer: High-dose iron will produce more total absorbed iron, but will also leave more in the gut, which could cause constipation or disturb the gut microbiome. If desperate for quick relief, 200 milligrams per day of iron taken in the morning will work faster than lower doses or the same dose taken in the afternoon. For most people, however, I believe it is best to start with 18 milligrams of iron, and only increase it to 27 or 36 milli...
What cofactors are needed to synthesize and recycle BH4? | Masterjohn Q&A Files #319
July 17, 2023 14:00 - 13 minutes - 24.4 MBQuestion: What cofactors are needed to synthesize and recycle BH4? Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR). This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other fr...
Is It Important to Get Vitamin D Sulfate Specifically From the Sun? | Masterjohn Q&A Files #318
July 03, 2023 14:00 - 28 minutes - 53.2 MBQuestion: Is it important to get vitamin D sulfate specifically from the sun? Short Answer: It is important to get morning outdoor sunlight as close to every day as possible for your circadian rhythm, and to get some exposure to unprotected sunlight during the day when UV is available, but at doses less than needed to cause reddening, and it is equally important to always avoid burning. There are many reasons for this, and the cholesterol sulfate hypothesis — to which the vitamin D sulfat...
When to Consider Inborn Errors of Metabolism
June 24, 2023 11:41 - 23 minutes - 387 MBThese are considered rare, yet this reinforces the pattern of never looking for them, leading them to likely be massively under-diagnosed. Many are highly relevant to nutrition. Written Version: https://chrismasterjohnphd.substack.com/p/when-to-consider-inborn-errors-of Mitochondrial Energy Summit: https://drtalks.com/mitochondrial-summit/?uid=406&oid=47&ref=3053 My MTHFR Protocol: https://chrismasterjohnphd.substack.com/p/mthfr-protocol
How to Recover From Fish Oil
June 23, 2023 21:19 - 44 minutes - 102 MBIris from Denmark has generously donated an hour of her consulting time with me to you, the community, so that her case can be used to raise awareness of the importance of arachidonic acid and the pitfalls of getting too much EPA. In this podcast, we cover: 00:27 Iris's history of too much omega-3 and not enough omega-6. 01:52 The symptoms that have improved upon reversing this. 04:54 Is it correct that the body needs both arachidonic acid and DHA to resolve inflammation? 09:03 ...
Can B12 and Folate Help Detoxify Oxalate?
June 23, 2023 19:51 - 16 minutes - 12 MBThis may explain why high-dose biotin causes "oxalate dumping" symptoms in some people but not others. Written and referenced version: https://chrismasterjohnphd.substack.com/p/can-b12-and-folate-help-detoxify Mitochondrial Energy Summit: https://drtalks.com/mitochondrial-summit/?uid=406&oid=47&ref=3053 My MTHFR Protocol: https://chrismasterjohnphd.substack.com/p/mthfr-protocol
If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? | Masterjohn Q&A Files #317
June 19, 2023 14:00 - 20 minutes - 39.3 MBQuestion: If a person has a hereditary weakness for Branched Chain Amino Acid Catabolism would this impact the type of diet they might choose to loose weight? Should they limit protein if it will increase their need for nutrients like Biotin?What are all the possible cofactors we should consider supplementing to support Leucine catabolism? Short Answer: Metabolizing branched-chain amino acids requires all B vitamins except folate, calcium, magnesium, potassium, and chloride. If you have a ...
How do I consume omega-3 without hurting my omega-6 status? | Masterjohn Q&A Files #316
June 05, 2023 14:00 - 24 minutes - 46.1 MBQuestion: If I don’t want to hurt my omega 6 status through my omega 3 intake, how do I do that? Is it simply a question of taking them at separate times? Or is it a question of dose? And if it is a question of dose, how do I know when to start eating fish and taking my omega 3 supplement again? Short Answer: How they are combined in meals is not important, but it is important not to have too much EPA in cell membranes relative to arachidonic acid, and this is driven by cumulative intake o...
Energy Metabolism Governs Everything
May 31, 2023 00:41 - 42 minutes - 77.9 MBThat was not an exaggeration. Everything. In this podcast I cover why riboflavin abolished my allergies, why a respiratory chain disorder could cause an autoimmune condition, and why a hypothetical athlete who went keto to take home the silver might be able to use thiamin to take home the gold. Most importantly, I cover why these are idiosyncratic needs, not general rules. The generalizable principle is that nothing is more central to life and health than energy. Read the written ve...
Can plant foods and their phytochemicals be used to reduce arterial plaque? | Masterjohn Q&A Files #315
May 22, 2023 14:00 - 28 minutes - 52.9 MBQuestion: Can plant foods and their phytochemicals be used to reduce arterial plaque? Short Answer: Yes, but if you don’t have specific intolerances to plant compounds the best thing to do is simply aim to meet your vitamin and mineral targets from a diet rich in fruits, vegetables, herbs, and spices, rather than trying to use specific plant compounds from specific studies in any specific amount. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this e...
What to Do About Twitching | Masterjohn Q&A Files #314
May 08, 2023 15:00 - 7 minutes - 13.8 MBQuestion: What can be done about twitching? Short Answer: Most twitching will be driven by glutamate/GABA balance or acetylcholine regulation, and the most likely nutritional issues are any of the electrolytes or any factor that influences energy metabolism. The best way to address it is to consider the conditions that influence it and then trial and error your way through each potential nutritional issue in order of which ones make the most sense for your individual case first. This ...
Can Biotin Help Detoxify Oxalate?
April 19, 2023 23:05 - 40 minutes - 61.8 MBThis is a hypothesis that may reconcile some anecdotes and has many hints suggested in the enzymological literature. First, make sure you get my MTHFR Protocol, my free 7-page quick guide to optimizing and personalizing your methylation status, here: https://chrismasterjohnphd.com/blog/2019/03/01/start-here-for-mthfr-and-methylation For the written version with references, as well as the 58 comments, including from Susan Owens, head over to Substack: https://chrismasterjohnphd.subs...
Vitamin K2 and Undercarboxylated Osteocalcin | Masterjohn Q&A Files #313
April 17, 2023 15:00 - 17 minutes - 33.5 MBQuestion: If undercarboxylated osteocalcin has health benefits, and vitamin K2 decreases it, what does that mean for K2 supplementation? Short Answer: Vitamin K2 helps secure osteocalcin in bone matrix, where it is decarboxylated and released as an endocrine hormone in response to certain stimuli. When released, it acts to optimize insulin secretion, insulin sensitivity, fuel use during exercise, and male testosterone. This is a clip from a live Q&A session open to CMJ Masterpass memb...
Self Experiments In the Biochemically Unoptimized State
April 12, 2023 14:25 - 3 hours - 294 MBFinally, the long-awaited results of my self-experiments conducted from September through January are released! First, make sure you get my MTHFR Protocol, my free 7-page quick guide to optimizing and personalizing your methylation status, here: https://chrismasterjohnphd.com/blog/2019/03/01/start-here-for-mthfr-and-methylation The primary abnormalities in my metabolism during this pre-biotin period were 1) 15 minutes of paradoxical rise in ketones after eating rice, 2) paradoxical rise...
My MTHFR Protocol
April 12, 2023 11:46 - 49 seconds - 19 MB VideoI have a free gift for you. That is my MTHFR Protocol, a 7-page quick guide to optimizing and personalizing your methylation status using foods and supplements. My MTHFR Protocol is free to anyone who subscribes to my Substack, whether free or paid. Use this link to get your copy: https://chrismasterjohnphd.substack.com/p/mthfr-protocol I hope you enjoy your free gift and find it useful.
Getting to the Bottom of My Health: Biotin and (V)LCAD
April 06, 2023 13:50 - 1 hour - 185 MBFor nearly 20 years, I have strongly suspected that I have a genetic disorder in synthesizing or recycling something that is absent or poorly available from plant foods, is very rich in organ meats, and is not present in any of the supplements I was taking when I was a vegan. After six months of research, testing, and self-experimenting, I now believe what I have been looking for is a mix of moderate genetic defects in biotin recycling, possibly combined with poor cellular uptake of biotin...
Phosphatidylcholine and TMAO | Masterjohn Q&A Files #312
April 03, 2023 15:00 - 21 minutes - 40.9 MBQuestion: If I'm at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement? Short Answer: On a scale of one to ten, my concern about TMAO and cardiovascular disease is a three. There are thousands of things that should be given equal weight as potential contributors to heart disease, but TMAO gets the most attention because the Cleveland Clinic has an incredible PR machine to spread their research, which serves to bolster their financial interest in...
Does Erythritol Cause Heart Disease?
March 24, 2023 16:43 - 48 minutes - 44.5 MBThis analysis of the recent study by the Hazen group at Cleveland Clinic published in Nature Medicine claiming erythritol contributes to cardiovascular disease shows the following: Why elevated plasma erythritol is likely to reflect thiamin deficiency and NADPH depletion from insulin resistance, inflammation, and oxidative stress Why the in vitro and mouse study blood clotting likely reflects osmotic stress with no relevance to the use of erythritol as a sweetener. Why I strongly suspect ...
Low Blood Sugar on Vegan Keto | Masterjohn Q&A Files #311
March 20, 2023 14:00 - 15 minutes - 29.1 MBQuestion: How do I fix low blood sugar on vegan keto? Short Answer: Consider how important it is for your ketones to be elevated. Most likely you need to eat more protein, which will lower your ketones. I would aim for a minimum of 0.8 grams per kilogram of ideal bodyweight and consider using 1.2 grams per kilogram of ideal bodyweight. If this does not work, consider all of the nutrients involved in energy metabolism — all of the B vitamins, iron, copper, sulfur, magnesium, potassium — bu...
Brain Fog on Calcium, Vitamin D, or K2 | Masterjohn Q&A Files #310
March 06, 2023 15:00 - 25 minutes - 47.7 MBQuestion: Why would vitamin D, vitamin K2, and calcium give me brain fog? Short Answer: Most likely by decreasing serum phosphorus. The solution is to balance these nutrients with vitamin A and phosphorus. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will al...
Why Plasma Zinc is the Best Marker of Zinc Status | Masterjohn Q&A Files #309
February 20, 2023 14:00 - 22 minutes - 43.1 MBShort Answer: Plasma zinc is the single most important marker of zinc status. Urine zinc may decline faster in deficiency. Hair zinc increases with supplementation but does not decrease in deficiency. Plasma zinc is decreased by inflammation, oxidative stress, the ovulatory and luteal phases of the menstrual cycle, probably pregnancy and oral contraceptive use, and any kind of stress that leads to an adrenal output. If plasma zinc declines despite supplementation, corroborate that this refle...
Glutathione Intolerance: Getting to the Bottom of It | Masterjohn Q&A Files #308
February 06, 2023 14:00 - 29 minutes - 55.5 MBShort Answer: It could be byproducts of any of the three amino acids that make up the glutathione molecule, which include the individual amino acids, ammonia, hydrogen sulfide, sulfite, and propionyl CoA, or it could be microbial metabolites of glutathione produced in the gut. The full answer contains seven hypothesis-driven tests that can be done at home to determine the cause. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can acce...
Statins Vs. Sulfur for Heart Disease | Masterjohn Q&A Files #307
January 23, 2023 15:00 - 28 minutes - 54.4 MBShort Answer: From the trials, statins seem to reduce heart disease risk and total mortality, but it is impossible to separate this from conflicts of interest and industry funding. There are plausible mechanisms by which they may hurt mitochondrial function and promote soft tissue calcification. Dietary sulfur appears to lower cholesterol. While Lester Morrison showed 1500 milligrams per day of chondroitin sulfate could reduce cardiac events 7-fold, this has a theoretical potential to hurt t...