Host Luke Burbank and announcer Elena Passarello recount the most impactful things anyone has ever said to them; actor Connor Ratliff explains how being fired by Tom Hanks inspired his hit podcast Dead Eyes, through which he unpacks showbiz rejection; professor of neuroscience Dr. Carl Hart makes the argument for responsible drug use; and folk icon and activist Ani DiFranco reflects on making her 22nd album Revolutionary Love with masked musicians during a pandemic.