Mitochondria and Amplifying Adaptation with Professor David Bishop #193

View all show notes and timestamps on the KoopCast website.

Episode overview:

Professor Bishop is a world leader in muscle exercise physiology, with over 250 scientific publications. He leads the Skeletal Muscle and Training research group at Victoria University in Australia.

The focus of his research group is to examine how diet, exercise, and genes interact to regulate skeletal muscle adaptations.

Throughout his career, Professor bishop has held many different and important leadership positions within the exercise science community in Australia.  He was the youngest-ever president of Exercise & Sport Science Australia (ESSA). He has been named one of the top 25 influencers of exercise & sports sciences in Australia. He has twice been on the Excellence in Research Australia (ERA) panel. He was made a fellow of three different organizations, Exercise and Sports Science Australia (ESSA), the American College of Sports Medicine (ACSM), and the European College of Sports Science (ECSS). Professor Bishop is now a director of the Victorian Institute of Sport (VIS) and an assistant editor of Medicine and Science in Sports and Exercise.

Episode highlights:

(19:56) Physiological limits to mitochondrial mass: homeostasis and why athletes plateau, mitochondria can never be 100% muscle mass, car analogy and spatial limitations

(43:29) Acute responses to training with low carb availability: cell signaling and mitochondrial benefits at lower intensities, no benefit at high intensities, train low can augment moderate intensity, recovering from low carb takes time

(54:12) Mechanisms of sodium bicarbonate: lactate and hydrogen ions move down concentration gradients, sodium bicarbonate lowers blood acidity by pulling hydrogen ions out of the muscle, applications to anaerobic performance

Additional resources:

David’s Twitter

Podcast with Renee Eastman on Physiological Testing

Mighty Mitochondria with Iñigo San Millán

Effects of Dietary Supplements on Adaptations to Endurance Training

Principles of Exercise Prescription, and How They Influence Exercise-Induced Changes of Transcription Factors and Other Regulators of Mitochondrial Biogenesis

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