Glutathione depletion in chronic alcohol abuse makes lungs vulnerable to life-threatening diseases

Chronic alcohol abuse causes a profound deficiency of the antioxidant glutathione in the lungs, generating a marked susceptibility to serious lung diseases, We now know that as many deaths occur every year from alcohol abuse related to lung injury as occur from alcohol abuse and liver disease or alcohol abuse Although glutathione is manufactured in a variety of organs and tissues, including the liver, the lungs are particularly dependent on glutathione for protection from oxidative damage, especially in the small airways where breathing takes place. The lack of glutathione in the lungs leads to a variety of abnormalities

including damage to the epithelial cells and fluid that lines the lungs, changes in the barrier function of lung cells and increased susceptibility to apoptosis, or cell death in the lungs