The rise in opioid prescribing and subsequent growth of opioid abuse has led to increased oversight and challenges for clinicians who prescribe opioids to their patients.  Recommendations and guidance documents vary when recommending approaches to monitor patients receiving controlled substances. In this podcast, we will explore drug testing for pain management from the prescriber’s perspective.  A Laboratory Reflection “Reflections of Two Pain Medicine Clinicians in the Era of the Opioid Crisis” was published in the January 2018 special issue of JALM on Laboratory Support of Pain Management.