Generation of Highly Biomimetic Quality Control Materials for Noninvasive Prenatal Testing Based on Enzymatic Digestion of Matched Mother–Child Cell Lines
JALM Talk Podcast
English - July 16, 2019 17:12 - 11 minutes - 15.2 MB - ★★★★★ - 4 ratingsMedicine Health & Fitness Science Chemistry Homepage Download Apple Podcasts Google Podcasts Overcast Castro Pocket Casts RSS feed
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Non-invasive prenatal testing based on cell-free DNA is now a widely used technique. However, quality control materials that have properties identical to clinical samples and that are applicable to a wide range of procedures are not available to support assay development, internal or external quality control, and proficiency testing. The June 2019 issue of Clinical Chemistry includes a study describing the development of such quality control materials that comprise simulated human plasma and mixtures of mother cell line derived cell-free DNA based on DNA fragmentation factor digestion.