Clinical laboratories play a crucial role in emergency medicine through toxicology and drug testing.  The type of testing provided is often a balance between laboratory resources and the patient population served.  Each approach to drug screening comes with advantages and disadvantages depending upon the specific drug exposure or illicit drug suspected. A “Case of Sudden Acute Coma Followed by Spontaneous Recovery” was published in the November 2018 issue of The Journal of Applied Laboratory Medicine.  The Case Study details the presentation and resolution for an unresponsive patient admitted to the hospital with a history of drug and alcohol abuse with a negative urine drug screen.