Myriad Live - Let's Talk PRS

Inside the GENOME

English - June 14, 2021 22:00 - 56 minutes - 39 MB
Medicine Health & Fitness Science genetics oncology cancer hereditary testing genetic testing brca cancer genetics Homepage Download Google Podcasts Overcast Castro Pocket Casts RSS feed

Previous Episode: MOL - Let's Talk Tumor vs. Germline Testing and Everything In Between

Next Episode: Myriad Live - Let's Talk Cancer Survivorship

Myriad Oncology Live episodes are recordings of an open-forum webinar hosted by Dr. Thomas Slavin. The opinions and views expressed in this recording do not necessarily represent those of Myriad Genetics or its affiliates. To participate in a future recording, visit myriad-oncology.com/myriad-oncology-live for a list of dates, times, and subjects.

Many studies were referenced in this episode, please see links below:

Yanes T, et al. Clinical applications of Polygenic breast cancer risk: a critical review and perspective of an emerging field. Breast Cancer Res 22, 21 (2020). https://pubmed.ncbi.nlm.nih.gov/32066492/

Mars et al study link: https://www.nature.com/articles/s41467-020-19966-5

Rosner et al study: https://cebp.aacrjournals.org/content/cebp/early/2020/12/04/1055-9965.EPI-20-0900.full.pdf

Lakeman et al study: https://www.nature.com/articles/s41436-020-0884-4

Barnes et al study: https://www.nature.com/articles/s41436-020-0862-x

https://www.nature.com/articles/ng.3841

https://pubmed.ncbi.nlm.nih.gov/25862352/

This is the study where the chart comes from : https://pubmed.ncbi.nlm.nih.gov/32620971/

Here is the abstract from ASCO about ancestrally unbiased breast cancer (BC) risk assessment. Dr. Pederson also presented this material during the meeting. https://meetinglibrary.asco.org/record/197017/abstract

Here is the Tischkowitz paper Dr. Slavin was discussing: https://www.acmg.net/PDFLibrary/41436_2021_1151_OnlinePDF.pdf

Gallagher paper (chart was from this paper) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2767768

Yanes T, et al. Women's responses and understanding of polygenic breast cancer risk information. Fam Cancer. 2020 Oct;19(4):297-306. https://pubmed.ncbi.nlm.nih.gov/32430685/

https://cancerpreventionresearch.aacrjournals.org/content/early/2020/10/23/1940-6207.CAPR-20-0154?versioned=true

Hughes et al paper where data from chart is derived: https://ascopubs.org/doi/full/10.1200/PO.20.00246

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score https://ascopubs.org/doi/full/10.1200/JCO.20.01992

Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer https://www.nejm.org/doi/full/10.1056/NEJMoa2105215