Biochemistry & Molecular Biology of Serotonin Receptors, Tryptamines & Psychedelics | Ryan Gumpper | M&M #102

Mind & Matter

English - January 12, 2023 22:00 - 1 hour - 51.3 MB - ★★★★★ - 15 ratings
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Previous Episode: Consciousness, Anesthesia, Coma, Vegetative States, Sleep Pills (Ambien), Ketamine, AI & ChatGPT | Alex Proekt | #101

Next Episode: Connections Between Microbiome, Exercise, Diet, Metabolism, Circadian Rhythms, Endocannabinoids & Health | Christoph Thaiss | #103

Nick talks to biochemist & biophysicist Dr Ryan Gumpper, a postdoc in Dr. Bryan Roth's lab at the University of North Carolina. They discuss the biochemistry, molecular biology & biophysics of serotonin receptors, including the molecular details for what happens when serotonin and tryptamines psychedelics (e.g. LSD) bind to 5HT2A receptors in the brain. They also discuss how understand these details relates to the quest to discover novel psychedelic-derived compounds with therapeutic benefits, as well as the inspiration Ryan received from reading Alexander Shulgin's famous book, PIHKAL.

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