A Redesign for Yeast’s Genome, Chromosome by Chromosome - Jef Boeke, Weimin Zhang & Leslie Mitchell

Genome Insider

English - June 28, 2024 12:00 - 20 minutes - 14.4 MB
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Previous Episode: Forest Fungi, Seagrass, and a New View of Symbiosis

To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone Health) and Leslie Mitchell (Neochromosome) have worked to replace yeast’s native chromosomes with synthetic versions. This project has turned out to be an international collaboration, with some artistic endeavors along the way. Eventually, the goal is to create an entirely human-generated yeast genome.

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Episode TranscriptPaper: Manipulating the 3D organization of the largest synthetic yeast chromosomeNYU Release: Researchers Assemble Nine Synthetic Yeast Chromosomes

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