Episode 12- "Clot Busters:" Part 1: Submassive and massive pulmonary embolism

In Part 1 of 2 of our "Mini Grand Rounds" series, we discuss the use of thrombolytics in the setting of submassive and massive pulmonary embolism. Tune in as we review studies and guidelines that discuss these agents in these settings, as well as appropriate dosing and administration of alteplase.

References:

Konstantinides S, Geibel A, Heusel G, et al. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. NEJM. 2002; 347(15): 1143-1150

Sharifi M, Bay C, Skrocki L, et al. Moderate Pulmonary Embolism Treated With Thrombolysis (from the "MOPETT" Trial). Am J Cardiol. 2013; 111(2): 273-277

Meyer G, Vicaut E, Danays T, et al. Fibrinolysis for patients with intermediate-risk pulmonary embolism. NEJM. 2014; 370: 1402-1411

Wang, et al. Efficacy and safety of low dose recombinant tissue-type plasminogen activator for the treatment of acute pulmonary thromboembolism. Chest. 2010; 137(2): 254-262

Zhang, et al. Lower dosage of recombinant tissue-type plasminogen activator (rt-PA) in the treatment of acute pulmonary embolism: a systematic review and meta-analysis. Thrombosis Research. 2013;133: 357-363

Disclaimer: 
The information contained within the  ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution,  seek medical advice from a licensed physician,  and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of,  any medical institutions, educational facilities, or other healthcare programs.

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Disclaimer:

The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.