86. Synthetic biology

In this episode of Discovery Matters, hosts Dodi and Conor explore how synthetic biology can lead to transformative breakthroughs when it comes to dealing with global health problems. Through their conversation with Justin Vigar, a PhD student in Dr. Keith Pardee's lab at the University of Toronto in Canada, we learn how his team's paper-based diagnostic tool has the potential to provide faster, more cost-efficient, and accessible diagnostics for underserved locations. This is complemented by Amir Pandi and Tobi Erb's discussion of using AI and synthetic biology to develop new antimicrobial peptides.

Show notes

• U of T PhD student uses synthetic biology to create low-cost diagnostic tools.

• Pandi, A., Adam, D., Zare, A. et al. Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nat Commun 14, 7197 (2023). https://doi.org/10.1038/s41467-023-42434-9

• Khalek IS, et al. Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins. Sci Transl Med. 2024 Feb 21;16(735). https://doi.org/10.1126/scitranslmed.adk1867

• Josh A Goldstein, Jason Chao, Shelby Grossman, Alex Stamos, Michael Tomz, How persuasive is AI-generated propaganda?, PNAS Nexus, Volume 3, Issue 2, February 2024. https://doi.org/10.1093/pnasnexus/pgae034