BrainWaves: A Neurology Podcast
217 episodes - English - Latest episode: almost 3 years ago - ★★★★★ - 166 ratingsBrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology and medicine. Follow us on Twitter @brainwavesaudio, or just tune in every Thursday for the latest shows! **NOT FOR CLINICAL DECISION MAKING**
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Episodes
#30 GBS: 2021 Update
May 06, 2021 13:26 - 19 minutes - 35.3 MBThis week on the program, we have remastered one of our earliest (and most interesting!) episodes on Guillain-Barre syndrome. With an important announcement from Jim Siegler. Produced by James E. Siegler. Music courtesy of Lee Rosevere. The opening theme was composed by Jimothy Dalton. Sound effects by Mike Koenig and Daniel Simion. Unless otherwise mentioned in the podcast, no competing financial interests exist in the content of this episode. BrainWaves' podcasts and online content are i...
#181 A primer on ICP management
April 22, 2021 09:00 - 35 minutes - 64.2 MBThe field of neurocritical care and traumatic brain injury management is rapidly evolving. We are shifting from older (but not entirely outdated) monitoring techniques to novel diagnostic and therapeutic advances in critical care medicine. Managing intracranial pressure crises involves the careful tiptoeing of a line between maintaining brain circulation and yet reducing intracranial fluid volume. And many of our interventions rely on one simple mathematical construct: CPP = MAP - ICP [C...
#180 The art of the pivot
April 08, 2021 09:00 - 16 minutes - 30.2 MBWhat do hip weakness, headache, and neglect have in common? At minimum, they can all be approached with simple neurodiagnostic heuristics. But there's more to neurology and medicine than having an approach to "leg weakness" or an approach to "headache". You have to adapt to new information as it presents itself. You have to know when, and how, to pivot. Produced by James E. Siegler, Minal Patel, and Jesse Thon. Voiceovers by Taryn Hester and Terri Yeager. Music for our program today was ...
#179 RBD and synucleinopathies
March 25, 2021 09:00 - 24 minutes - 45.8 MBWho doesn’t enjoy their sleep? For most of us, it can be the most relaxing escape. And for others, a disturbance of sleep may be the first clue to a neurodenerative condition. Produced by James E. Siegler. Dr. Avidan reports that he receives royalties from Elsevier, is a consultant for Merck, and is a speaker for Eisai and Harmony. Music for our program today was by Andy Cohen, Purple Planet Music, Steve Combs, Yan Terrien, and Shane Ivers, whose music can be found at silvermansound.com. Ou...
#178 First seizure of life
March 04, 2021 10:00 - 15 minutes - 29.2 MBAs many as 1% of the world has epilepsy, but far more than will have a seizure in their lifetime. Not everyone needs a seizure medication, some people are even harmed by them. So who warrants treatment, and what do you start with. Consider today’s program an intro to AED decision making. For educational purposes only, of course. Not to guide any healthcare provider’s decision making. Produced by James E. Siegler. Music courtesy of Lee Rosevere, Cellophane Sam, Jon Watts, Josh Woodward,...
#177 Agnosia
January 28, 2021 10:00 - 14 minutes - 27.2 MBTo quote Donald Rumsfeld, “there are things we know we know…. we know there are some things we do not know... But there are also unknown unknowns—the ones we don't know we don't know…it is the latter category that tends to be the difficult ones.” In neurology, the agnosias are not that dissimilar from Rumsfeld’s 'unknown unknowns.' In this week’s program, we discuss the nosology and nomenclature for the agnosias, the localization, and the importance of recognizing one. Produced by James ...
Best of BrainWaves 2020
December 31, 2020 10:00 - 1 hour - 124 MBHappy New Year, and good riddance 2020! Hopefully there is more that you will take away from the past 12 months other than your personal experience with the coronavirus pandemic. Whether you lost a job, a loved one, or an invaluable life experience, I think we can all say BRING ON 2021! So let's welcome the new year with positive mental attitude, a bit more luck, and an unquenchable thirst for knowledge. Produced by James E. Siegler. Music courtesy of Jahzzar, Kevin McLeod, Patches, Montpl...
#176 Mind blown
December 17, 2020 10:00 - 30 minutes - 55.1 MBI shouldn’t have to tell you that traumatic brain injury is a major cause of morbidity and mortality. I shouldn’t have to. But I will. And it is. In severe cases of head injury, there can be delayed and irreversible deterioration in the nervous system for which there is no treatment and the prognosis is grim. This week on the program, Dr. Monisha Kumar (University of Pennsylvania) discusses the worst of the worst of these scenarios, what to look out for, and expert recommendations on what to...
#175 Call your Mom
December 03, 2020 10:00 - 20 minutes - 37.7 MBCOVID-19 is more than just a threat to your physical health. Even if you are never infected, you may not be free of it. In today's program, we take lessons from prior pandemics and consider the sociocultural effects of a global infectious disease. Be advised, this one is of the "sentimental" variety. Produced by James E. Siegler. Music courtesy of Purple Planet Music, Meydn, Kevin MacLeod and Shane Ivers, which you can find at Silvermansound.com. The opening theme was composed by Jimothy...
#174 The mental status
November 19, 2020 10:00 - 29 minutes - 54.6 MBThe mental status exam is a keystone of the neurologic assessment. Dr. Andrea Casher (Cooper University Hospital) builds upon this metaphor in our program this week. Making a special appearance is US President Donald Trump, who underwent a mental status exam and recounts his experience. Produced by James E. Siegler and Andrea Casher. Music courtesy of Unheard Music Concepts, Purple Planet Music, Lee Rosevere, and Scott Holmes. The opening theme was composed by Jimothy Dalton. Sound effects...
#93 Aspirin vs. Plavix: The showdown
October 29, 2020 09:00 - 20 minutes - 37.3 MBOctober 29 is World Stroke Day! Might as well know how it is best treated. This week, Jim Siegler revisits a 2017 episode on the differences between two of the most commonly prescribed post-stroke treatments, with some key updates, recent trial results, and practice-changing paradigms. Produced by James E. Siegler. Music courtesy of William Ross Chernoff’s Nomads, Steve Combs, Rui, Little Glass Men, and Peter Rudenko. The opening theme was composed by Jimothy Dalton. Sound effects by Mik...
#173 Matching during the COVID-19 pandemic
October 22, 2020 09:00 - 31 minutes - 57.7 MBThis week on the program, we bring to you a special episode on the impact of the COVID-19 pandemic on the neurology 2021 match--and potentially MANY subsequent matches. Jim Siegler is joined by the Assistant Program Director of the Cooper Neurology Residency Program, Olga Thon, and the creators of the @NMatch2021 Twitter account (who you should DEFINITELY follow after listening to our episode). If you are an applicant for the 2021 cycle, this show is MANDATORY. (only kidding, this is just ...
#83 Halloween Special: Zombies in neurology
October 15, 2020 09:00 - 24 minutes - 45.7 MBHalloween is one of the most exciting and festive holidays, but this year I imagine many of us are going to spend it indoors. To help pass the time, enjoy this seasonal special about the neurologic manifestations of zombie-ism. Today's program is a re-run from 2017, featuring Dr. Brian Hanrahan, and has been remastered and updated with some recent additions in light of the coronavirus pandemic. Produced by James E. Siegler. Music courtesy of Andrew Sacco, Ars Sonor, Yan Terrien, and Unhear...
#172 Cavernoma
October 01, 2020 09:00 - 18 minutes - 33.3 MBAs the second most common vascular malformation in the central nervous system, cerebral cavernomas are often incidental radiographic findings. Also incidental is Jim’s interest in mediocre sci-fi television shows, such as Netflix’s recent series, Away—which incidentally includes one character with a symptomatic cerebral cavernoma. This week on the podcast, Dr. Siegler discusses with Dr. Dena Little (Cooper University Hospital) the epidemiology, clinical course, and management (including coun...
#171 High-convexity tight sulci
September 17, 2020 09:00 - 10 minutes - 19.3 MBYou know the triad for normal pressure hydrocephalus (NPH). Wet, wobbly, and wacky. And you have probably heard of the Evan’s index—the relative proportion of the lateral ventricles in reference to the inner table of the skull. But you might not have heard of high-convexity tight sulci. Now you have. Produced by James E. Siegler. Music courtesy of Jason Shaw, Javolenus, and Lee Rosevere, under a Creative Commons License. The opening theme was composed by Jimothy Dalton. Sound effects by ...
#170 Myoclonus and neurodegenerative diseases
September 03, 2020 09:00 - 25 minutes - 47.1 MBMyoclonus is the most etiologically non-specific motor manifestation of neurologic and systemic disease. It’s like slurred speech or altered mental status. But in the appropriate context, it can become a useful clue in your differential diagnosis. Dr. John Caviness of the Mayo Clinic joins Jim Siegler this week for a discussion on this abnormal movement and what it may indicate. Produced by James E. Siegler and John Caviness. Music courtesy of Kevin McLeod and E’s Jammy Jams. “Endings” and...
#109 Misnomers in medicine: Low grade glioma
August 20, 2020 09:00 - 25 minutes - 46.4 MBA lot can happen in two years. You might have matched into residency, graduated from fellowship, had a kid... Or several phase II trials in low grade glioma research could have been published. Since the original airing of this episode in May 2018, there have been a few updates in neuro-oncology. We'll cover some of the major ones this week in the BrainWaves podcast. Produced by James E. Siegler, Brian Nahed and Jorg Dietrich. Music courtesy of Ian Sutherland, Lovira, and Lee Roosevere. T...
#169 The interictal EEG
August 06, 2020 09:00 - 22 minutes - 41.2 MBThe electroencephalogram is a nearly 100-year old neurodiagnostic instrument. And yet, we learn new things from it every day. This week on the BrainWaves podcast, Dr. Tracey Milligan (Mass General Brigham) reviews the indications and utilization of a routine scalp EEG. Also discussed: Limitations of scalp EEG Brain surgery Non-epileptic events Why YOU should consider becoming an epileptologist Produced by James E. Siegler and Tracey Milligan. Music courtesy of Steve Combs, Lee Roosev...
#168 (Mis)understanding the locked-in state
July 23, 2020 09:00 - 26 minutes - 48 MBThe locked-in syndrome is a rare clinical consequence following many types of neurologic injury. In general, the locked-in patient is fully paralyzed, with perhaps minimal function of the fingers, the eyes, or the mouth. What's more, the gross motor dysfunction is enormously disproportional to the cognitive function of the individual. The locked-in patient is conscious and completely aware of their surroundings. They can often hear, see, smell, and feel just as any other person would. But be...
#167 The role of sinovenous stenosis in IIH
July 09, 2020 09:00 - 16 minutes - 30.2 MBWebster defines ‘idiopathic’ as “arising spontaneously or from an obscure or unknown cause”. By definition, this means idiopathic intracranial hypertension (IIH) has no proximate cause. But that’s not exactly true. This week on the podcast, we explore the recent evidence behind the theory that transverse sinus stenosis may contribute to this condition. Disclaimer: No chicken or eggs were harmed in the making of this episode. Produced by James E. Siegler. Music courtesy of Squire Tuck, Sw...
#166 Not just a headache
June 25, 2020 09:00 - 33 minutes - 60.7 MBIt’s more than just a headache. Migraine is a disturbance of normal neurological function, and as you are aware, it causes more than just severe head pain. This week on BrainWaves, Dr. Deborah Friedman (UT Southwestern) shares her experience evaluating and managing the unusual neurologic manifestations of migraine that aren’t just the misery from recurrent attacks. Produced by James E. Siegler & Deborah Friedman. Music courtesy of Josh Woodward, Kevin McLeod and Lee Rosevere. The opening t...
#165 How the other half lives
June 11, 2020 09:00 - 23 minutes - 43.2 MBOn rounds, I sometimes joke that the two most important organs in the body are the right and left hemisphere. Only one of many, terrible, dad jokes my poor residents and students have to endure. But what happens when one organ fails, or you have to remove it? This week on BrainWaves, we’ll review a unique neurologic condition where such incredible hemispheric dysfunction can only be treated by surgically removing half of the brain. And OMG, a show about pediatrics! ** IF YOU’RE TAKING YO...
#164 Lewy Body Dementia
May 28, 2020 09:00 - 25 minutes - 46.8 MBLewy Body Dementia may be the second most common neuropathologic cause of dementia behind Alzheimer disease, but it remains largely a clinical diagnosis with limited treatment options. This week on BrainWaves, Dr. Amy Colcher (Cooper University Hospital) reviews the diagnostic criteria and management strategies for patients and their caregivers who suffer from this condition. Plus, a sort of tribute to Robin Williams. ** IF YOU’RE TAKING YOUR NEUROLOGY BOARDS THIS SUMMER, CHECK OUT THE...
#163 What’s the buzz?
May 14, 2020 09:00 - 23 minutes - 42.2 MBCan you hear that too? You can’t? Well, that doesn’t mean I’m having auditory hallucinations. It could just be tinnitus, which describes the irritating sound of ringing, buzzing, clicking, or hissing that affect 10-20% of the world's population. But is this a ringing in the ears, or a ringing in the brain? ** IF YOU’RE TAKING YOUR NEUROLOGY BOARDS THIS SUMMER, CHECK OUT THE PENN NEUROLOGY BOARD REVIEW COURSE AT https://upenn.cloud-cme.com/default.aspx?P=5&EID=65373. AND FOR A DISCOUNTED RA...
#162 Just because you couldn't attend the AAN's annual meeting...
April 30, 2020 09:00 - 29 minutes - 53.5 MBIt’s 2020, and for the first time in its 72-year history, the American Academy of Neurology has cancelled its annual meeting because of the COVID-19 pandemic. But that does not mean we (BrainWaves producers, not the AAN) can’t provide a few major updates to advances in neurology and neurotherapeutics! This week on the program, Jim Siegler is joined by Dr. Sammita Satyanarayan (Stanford) on a whirlwind tour of some of the latest advances in neurology from this past year. Enjoy! ** IF YOU’RE...
#161 Rule out spinal dural AV fistula
April 16, 2020 09:00 - 28 minutes - 52.4 MBAs my wife and I are raising our 9-month old daughter, and she is eating more solid food, I can’t help but think about how important it is she keep an open mind to new food groups. But being open minded is not just a lesson for toddlers. I emphasize it every day on rounds when seeing patients for a “stroke consult”, or a consult for “ICU delirium”. If you reduce yourself to the same anchoring biases that you've grown accustomed to, you’ll never entertain the possibility of other important, a...
#160 Pluses and minuses of perfusion imaging
April 02, 2020 09:00 - 23 minutes - 42.3 MBPerfusion imaging employs concepts that date back to the early 1830s, and it leverages hardware and software that emerged around the same time at multidetector helical CT scans. But it has only become popular in recent years for thrombectomy decision-making. If I'm being honest, I often never use it for this purpose. So what other purposes might it serve? And how does it work? This week, we review the fundamental concepts of perfusion CT, its utility in stroke care, and how it might prove ...
Update: Musings on COVID-19
March 29, 2020 09:00 - 23 minutes - 43.3 MBImagine what it would have been like, to have lived in 1918. Spanish influenza killed approximately 3% of the world’s population. Other than the world war, international travel was fairly limited. There was no social media. No flu vaccine. No mechanical ventilators. No World Health Organization. A century later, we’re facing the next great pandemic. And what have we learned? What do we know? From the neurologic complications of SARS-CoV-2, to non-infectious consequences, the environmenta...
#159 The pupil can be a great teacher
March 19, 2020 09:00 - 25 minutes - 46.7 MBThey say the eyes are the window to the soul. Well, maybe. They also happen to be the first organ we (perhaps, unknowingly) examine whenever we encounter a patient. This week on the program, we build on the prior episode about anisocoria (featuring Dr. Ali Hamedani, episode 74) and discuss the examination of the pupil, and all that these 3-5 millimeters of tissue can teach us. Plus, some Dad jokes at the end... Produced by James E. Siegler. Music courtesy of Chris Haugen, Daniel Birch, a...
#158 Teaching through clinical cases: A primer on proximal weakness
March 05, 2020 10:00 - 18 minutes - 34.1 MBGeneralized weakness is a common complaint. Much of the time, we as neurologists don’t even see these patients in the hospital or the clinic. But more often than not, “generalized” weakness may be the only way a patient describes difficulty brushing their hair or climbing stairs. In these situations, it’s not exactly generalized weakness. It’s something else. This week on BrainWaves, we review the major patterns of weakness that characterize the most common muscle disorders. With a quick rev...
#80 The meningitis that keeps coming back: 2020 update
February 27, 2020 10:00 - 30 minutes - 55.5 MBThis week on BrainWaves, we're revisiting the 2017 episode on recurrent meningitis featuring Dr. Jon Rosenberg (New York Presbyterian-Columbia). While we may not have made much headway in the treatment of these patients since the original show came out, we have made some progress in the neurodiagnostics. Produced by James E. Siegler and Jon Rosenberg. Music courtesy of Coldnoise, Three Chain Links, and Uncanny. Unless otherwise mentioned in the podcast, no competing financial interests exi...
#157 Checkpoint inhibitor neurotoxicity
February 20, 2020 10:00 - 25 minutes - 46.5 MBImmune checkpoint inhibitors have revolutionized cancer treatment. Unlike chemotherapy, which essentially includes cellular toxins that can cause widespread and unnecessary tissue damage, checkpoint inhibitors are used to train the body’s natural immune system to fight off the cancer. And while they are extraordinarily effective options for patients with malignant disease, they are not without risk. Every day, we are learning more and more about the autoimmune side effects of these novel the...
#156 Off-label clobazam in drug-resistant epilepsy
February 06, 2020 10:00 - 13 minutes - 25.3 MBThe sole FDA approved indication for clobazam is as a therapeutic adjunct in Lennox Gastaut Syndrome. But as more and more clinicians publish their experience with the off-label success of certain therapies, we may see new indications for this and other pharmacologic agents in the treatment of neurologic disease. Produced by James E. Siegler. Unless otherwise mentioned in the podcast, no competing financial interests exist in the content of this episode. Music courtesy of Chris Zabriskie, ...
#155 Teaching through clinical cases: Handed the diagnosis
January 23, 2020 10:00 - 18 minutes - 34.2 MBIn a patient with isolated, progressive hand numbness and weakness, there is a much to be learned about the clinical exam. Often, its all you need. This week, Dr. Aakriti Kothiwal (Cooper University Hospital) presents this week's clinical case and helps localize the lesion. Produced by James E. Siegler and Aakriti Kothiwal. Music courtesy of Jazzar, Lee Rosevere, and Loyalty Freak Music. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended fo...
#154 All that restricts does not infarct
January 09, 2020 10:00 - 21 minutes - 39.6 MBThe common teaching is that restricted diffusion on MRI indicates stroke—acute cerebral infarction. When, more specifically, the changes on DWI and ADC indicate impairment in the random movement of water molecules in a given tissue. With slower movement, as in energy-depleted tissues with failing ATP-dependent sodium/potassium channels, high cellularity, or a highly viscous extra-cellular space, there is restricted diffusion (of water) and a corresponding bright signal on DWI. These and othe...
Best of BrainWaves 2019
December 26, 2019 10:00 - 1 hour - 154 MB2019 was a big year. The year of the Mueller report. The American college admissions scandals. Brexit. But it was also the year the US Women's team won the World Cup, and lobbied for the equal pay of women and men in sports. It was the year of NMO, in which several pivotal trials showed benefit of disease modulating therapy in this condition. The year Will Smith played Genie in Aladdin. 2019 was a great year. And as we wrap up 2019, this week's episode includes some of the highlights. Enjo...
#153 Neurosarcoidosis: The 21st century great mimicker
December 12, 2019 10:00 - 34 minutes - 63 MBIn the TV show, HOUSE, it's either lupus or its sarcoidosis. Only, it's never sarcoidosis. That's because sarcoidosis is such a heterogeneous condition and can affect practically any age group. In some patients, this idiopathic inflammatory disorder can also involve the nervous system. Also causing a variety of signs and symptoms ranging from mild headache to a proximal myopathy or even a CNS vasculitis. This week on the BrainWaves podcast, Dr. Jesse Thon reflects on the literature and share...
#10 Cryptogenic stroke: 2019 update
December 05, 2019 10:00 - 23 minutes - 43.3 MBIn 2016, when we first launched the BrainWaves podcast, cryptogenic stroke was a poorly understood concept. 3 years later, it remains poorly understood. But we are making progress. In this week's update of episode 10, we review the progress that has been made in the pathogenesis, diagnosis, and management of these patients. Produced by James E. Siegler. The original 2016 version of this show was also produced by Dr. Noah Levinson. Music courtesy of Josh Woodward, Julie Maxwell, Dan Lebowit...
#152 It’s not over yet…part 2: Post-publication peer-review
November 28, 2019 10:00 - 20 minutes - 37.6 MBPeer review prior to publication of medical data dates back to the 9th century CE, but has only really gained steam in the past 70 or 80 years. Ideally, peer review would serve as an initial filter for data that enters a permanent public scientific record. But peer review is not without flaws. In the second installment of the BrainWaves segment, “It’s not over yet…”, we discuss publication as a potential source of bias, and highlight the reasons why it should not be the final step of the pee...
#151 It’s not over yet…part 1: Opening Pandora’s black box
November 14, 2019 10:00 - 26 minutes - 35.8 MBThe FDA label for ACTEMRA (tocilizumab)--the first medication approved for use in giant cell arteritis in 2017--is 40 pages long. Of the information provided in this document, which includes important dosing information, dose adjustments based on leukocyte count, clinical trial and epidemiologic data, there is a box of text on the first page of the insert. "WARNING: RISK OF SERIOUS INFECTIONS" it reads. What do you make of this warning? And with such a clear and broad-sweeping statement st...
Halloween special 2019: Young Frankenstein
October 31, 2019 09:00 - 26 minutes - 47.8 MBThis year, Halloween falls on a Thursday. So we've put together a special episode to celebrate it! But first...a question: What do Frankenstein's monster, Spock, and Rick Deckard all have in common? Find out in this week's episode of BrainWaves. Produced by James E. Siegler. Special guest, Scott Kasner (Hospital of the University of Pennsylvania) with fair use of material from Young Frankenstein (1974), Star Trek: The Original Series (1966-1969), and Blade Runner (1982). Music courtesy of ...
#150 Patient narrative part 2: It started with back pain…
October 17, 2019 09:00 - 24 minutes - 45.3 MBCollege is a tough time for any kid. But it should also be exciting. Then to experience the freedoms of young adulthood, only later to face the horrifying reality of a progressive neurodegenerative condition...it's not something anyone should experience. In this week's continuation of the patient narrative series, Dr. Paul McIntosh (Duke) shares his life-changing story, and his optimism, about surviving a chronic neurological illness. Produced by James E. Siegler with the help of Paul McIn...
#149 Patient narrative part 1: The world’s disability
October 03, 2019 09:00 - 29 minutes - 53.3 MBSara Henya would have you recognize her for her music, not her malady. While she may have Tourette Syndrome, she refuses to let it define her. In this week's episode of BrainWaves, we're launching a two part series featuring people who are living with a chronic neurologic illness--how they were diagnosed, how they cope with it, and of course, the neurobiology that underlies it. Produced by James E. Siegler with Dr. Michael Rubenstein and Sara Henya. Music courtesy of Sara Henya (find her m...
#34 The ALS multi-disciplinary clinic
September 26, 2019 09:00 - 28 minutes - 51.5 MBThis week on the program, our earlier episode on the multidisciplinary care of ALS patients gets a face lift. Since it originally aired in 2016, there have been several important advances in the treatment of these patients--including the first FDA approved therapy for this condition in more than 2 decades. But many of the core management strategies remain the same. Dr. Lauren Elman, Associate Professor of Neurology, Director of Research Operations and Associate Director of clinical care at t...
#148 Teaching through clinical cases: A curious case of infectious encephalitis
September 19, 2019 09:00 - 32 minutes - 44.1 MBIn this week's clinical case, Dr. Mike Bradshaw (Chicago Medical School and Billings Clinic) walks us through the case of a young woman with HSV encephalitis. With a twist. SPOILER ALERT: If you don't want to know the answer, DON'T LOOK AT THE SHOWNOTES! Produced by James E. Siegler and Mike Bradshaw. Music courtesy of Yan Terrien, Unheard Music Concepts, Steve Combs, and Montplaisir. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended f...
Quanta: PREVENTing relapses of Aqp4-Ab NMO
September 12, 2019 09:00 - 19 minutes - 36.3 MBWe just used clinical trial data regarding eculizumab in myasthenia gravis as an example of how to critically appraise the literature, and in this week's program...MORE data on the efficacy of eculizumab in another neurological condition. This week on BrainWaves, the exciting results of the PREVENT trial and the future treatment of NMO spectrum disorder! Produced by James E. Siegler. Special thanks to Dr. Olga Rosenveld Thon. Music courtesy of Unheard Music Concepts, TRG Banks, and Aitua. ...
#147 I wonder: p-value
September 05, 2019 09:00 - 27 minutes - 37.3 MBOne study shows that 30 minutes of exercise 5 times a week can reduce your risk of squamous cell carcinoma of the skin, p=0.001. (Let's pretend this is true). What does this mean? Well, let's start by asking the question, how IMPORTANT is it that you reduce your risk of SCC of the skin, and how MUCH does exercise reduce that risk? If the effect of exercise is associated with a relative risk reduction of 1% in your lifetime risk of SCC, is that enough to get you to spend 1 week of your life...
#146 Tangled up in squiggles: EEG 101 and the ictal inter-ictal continuum
August 22, 2019 09:00 - 43 minutes - 59.3 MBThis week on the BrainWaves podcast, finally...a REAL show about BRAINWAVES! Dr. Carolina Maciel, of the University of Florida, schools Jim Siegler on how to read EEG and interpret abnormal patterns across the ictal-interictal continuum. Produced by James E. Siegler and Carolina Maciel. Music courtesy of Chris Zabriskie, Montplaisir, Rafael Archangel, Steve Combs, Unheard Music Concepts, and Siddhartha. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content...
#145 Astroglia and Alzheimer’s disease
August 08, 2019 09:00 - 24 minutes - 33.2 MBClean up on aisle 4! Or should it be IL-4? In this week's installment of the BrainWaves Podcast, we submerge ourselves into the microscopic environment of Alzheimer's pathology. It's interesting, it's messy, and whoever made this mess is also responsible for the clean up. Produced by James E. Siegler. Music courtesy of Andy Cohen, Brendan Kinsella, Cuicuitte, Damiano Baldoni, Kai Engel, Nctrnm. Sound effects by Mike Koenig, Blastfx.com, Caroline Ford, Robertv, and Daniel Simion. BrainWav...
#144 RCVS vs. Primary Angiitis of the CNS
July 25, 2019 09:00 - 29 minutes - 40.1 MBA 50-year-old gentleman presents with severe headaches and speech disturbance. The MRI shows acute strokes and multifocal vascular irregularities. Is it reversible cerebral vasoconstriction syndrome or primary angiitis of the central nervous system? Or is it something else entirely? RCVS and PACNS almost always pose a challenge--even to the most astute neurologist. But, because they are treated entirely differently and their clinical trajectories depend on these treatments, it is worth kno...