Blood, Sweat and Smears - A Machaon Diagnostics Podcast

Mixing Studies

In this podcast our Medical Director, Dr. Brad Lewis, discusses mixing studies- more specifically what a mixing study is and what it isn't, as well as a few quirks we see in some of the mixing studies. Click here ➡️ https://bit.ly/47wN5fN for information on all the different mixing studies that Machaon Diagnostics performs.

Diagnosing Heparin-Induced Thrombocytopenia (HIT) and the role of HIPA Testing

In this podcast, our Medical Director, Dr. Brad Lewis, discusses heparin-induced thrombocytopenia, also known as HIT.  Dr. Lewis addresses what HIT is, how to diagnose and interpret testing, and the role of functional testing like the HIPA (Heparin-Induced Platelet Antibody) test.

Diagnosing and treating Hemophagocytic lymphohistiocytosis (HLH)

In this podcast, our Medical Director, Dr. Brad Lewis, talks with Dr. Scott Canna, from the Division of Rheumatology and the Immune Dysregulation Program at Children's Hospital of Philadelphia. Dr. Lewis and Dr. Canna discuss Hemophagocytic lymphohistiocytosis (HLH); what HLH is, treating and diagnosing HLH, and infections that make you particularly worried about the possibility of HLH developing.   Don't forget, Machaon offers genetic testing STAT results in 48 hours!

Diagnosing and treating aHUS in a 40-day-old patient

In this podcast, our Medical Director, Brad Lewis, discusses a  pediatric case of aHUS with Dr. Amara Finch, a Pediatric Resident Physician at the University of Utah. Dr. Finch presents a fascinating case of atypical hemolytic uremic syndrome (aHUS) in a 40-day-old patient. Using Machaon Diagnostics' fast turnaround time, physicians were able to get the results for their aHUS Genetic Panel, saving the patient who was to soon have discontinued care.   Comment from the physician: "We are all...

Renal transplants and the roles of testing around it

In this podcast, our Medical Director, Brad Lewis, talks with Dr. Christina Klein, a transplant nephrologist and the head of the transplant program at Piedmont Transplant Institute in Atlanta, GA.  Dr. Lewis and Dr. Klein discuss renal transplants and the different roles of testing around renal transplants (i.e. gene sequencing and soluble MAC).  They also discuss the functions of genetic testing for aHUS and complement activation in patients who are coming in for transplant evaluation. D...

Understanding next-generation sequencing (NGS)

In this podcast, our Medical Director, Brad Lewis, continues his conversation with Jamey Kain, Vice President of Genetic Innovation here at Machaon.  Brad and Jamey discuss what next-generation sequencing (NGS) is, why it's important and some of the issues we face with NGS. Don't forget, Machaon offers genetic testing STAT results in 48 hours!

How to Choose Panels for Next-Generation Sequencing (NGS)

In this podcast, our Medical Director, Brad Lewis, talks with Jamey Kain, Vice President of Genetic Innovation here at Machaon. Brad and Jamey discuss how we design our genetic panels, what goes in, what stays out and how we think about clinical utility and turnaround time considerations. Don't forget, Machaon offers genetic testing STAT results in 48 hours!

How to Choose Panels for Next Generation Sequencing (NGS)

In this podcast, our Medical Director, Brad Lewis, talks with Jamey Kain, Vice President of Genetic Innovation here at Machaon. Brad and Jamey discuss how we design our genetic panels, what goes in, what stays out and how we think about clinical utility and turnaround time considerations. Don't forget, Machaon offers genetic testing STAT results in 48 hours!

How to Chose Panels for Next Generation Sequencing (NGS)

In this podcast, our Medical Director, Brad Lewis, talks with Jamey Kain, Vice President of Genetic Innovation here at Machaon. Brad and Jamey discuss how we design our genetic panels, what goes in, what stays out and how we think about clinical utility and turnaround time considerations. Don't forget, Machaon offers genetic testing STAT results in 48 hours!

How to choose panels for next-generation sequencing (NGS)

In this podcast, our Medical Director, Brad Lewis, talks with Jamey Kain, Vice President of Genetic Innovation here at Machaon. Brad and Jamey discuss how we design our genetic panels, what goes in, what stays out and how we think about clinical utility and turnaround time considerations. Don't forget, Machaon offers genetic testing STAT results in 48 hours!

Psychological and Emotional Impact of VTE Diagnosis; Improving Patient Outcomes

Join Dr. Kerstin de Wit and our Medical Director, Dr. Brad Lewis, discuss the importance of accessing and educating patients with newly diagnosed venous thrombotic disease. Many patient factors, including age, sex, activity and knowledge levels should be considered to optimize acceptance and disease management. Providers can help patients minimize distress with careful questioning and listening skills.

From CLS to CEO, the story of Machaon Diagnostics

In this episode we hear an interview with Mike Ero, Machaon Diagnostics' Founder and CEO. A Clinical Laboratory Scientist (CLS) who added an MBA, Mike started Machaon Diagnostics back in 2003 at the age of 29. Just how did all of that come about? Listen and find out.  We hope you find our origin story interesting. You'll get a good sense of why we were founded and the mission we are fulfilling today. 

Bleeding Disorders in Women: Considerations pre, during & postpartum

Andra James, MD, MPH is a Professor of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Duke University Center, and consulting professor of Medicine, Division of Hematology. She is also the founder of Duke University's Women's Hemostasis and Thrombosis Clinic.  Dr. James and Machaon Diagnostics' Medical Director, Dr. Brad Lewis, discuss the various approaches to monitoring bleeding disorders (VWD, Platelet Disorders and mild Hemophilia) during critical time frames before, duri...

COVID-19 VITT - What we know so far

Our Medical Director, Brad Lewis, MD, discusses COVID-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) and diagnostic strategies. 

PAI-1 with Dr. Brad Lewis

In this episode Dr. Brad Lewis talks about PAI-1, testing for PAI-1 and where things look to be heading for the future of this gene and conditions associated with it. We released this episode to coincide with Pi Day (3.14).

Challenges in diagnosing Hemophagocytic Lymphohistiocytosis (HLH)

Join Michelle Hermiston, MD, PhD - Associate Professor of Pediatrics (Pediatric Hematologist/Oncologist) at UCSF and our Medical Director, Brad Lewis, MD, discuss the challenges of diagnosing Hemophagocytic Lymphohistiocytosis or HLH, possible triggers and approach to management. If you are interested in our 48-hour STAT check out the link for more information 👉 http://bit.ly/37rm28H. We can send you draw kits and are happy to talk you through the process/details.

aHUS in Pregnancy

Our Medical Director, Brad Lewis, MD, discusses aHUS/TMAs in pregnancy with Richard Burwick, MD, MPH - Assistant Professor, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Cedars-Sinai Medical Center. If you are interested in our 48-hour STAT aHUS Testing please let us know. We can send you draw kits and are happy to talk you through the process/details.

aHUS in Pregnancy

Our Medical Director, Brad Lewis, MD, discusses aHUS/TMAs in pregnancy with Richard Burwick, MD, MPH - Assistant Professor, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Cedars-Sinai Medical Center. If you are interested in our 48-hour STAT aHUS Testing please let us know. We can send you draw kits and are happy to talk you through the process/details.

Hypercoagulability and COVID-19 (Updated March 25, 2020)

Our Medical Director, Brad Lewis, addresses a number of questions around hypercoagulability and COVID-19.

soluble Complement 5b-9 (sC5b-9)

Dr. Brad Lewis discusses sC5b-9 in this podcast addressing; what sC5b-9 testing is, why you want to know about this test and when to use it. Dr. Lewis also explores how it helps when trying to confirm a diagnosis. 

Hemophagocytic lymphohistiocytosis (HLH)

Dr. Brad Lewis discusses hemophagocytic lymphohistiocytosis (HLH); when you want to think about HLH, why you want to think about HLH, and how to diagnose this disorder. 

Blood, Sweat and Smears - Post-Bone Marrow Transplant TMA

Dr. Lewis discusses TMAs in the post-BMT setting, recent research into the topic, when to think about it and what to do about it. 

Hypercoagulability explained for patients

Review of TMAs

Hypercoagulability Testing

Lab Testing for Patients Taking Hemlibra (Emicizumab-kxwh)

Blood, Sweat and Smears - Common errors and misconceptions around coagulation

Blood, Sweat and Smears - What to make of an equivocal aHUS result

Blood, Sweat and Smears - Diagnosing Thrombotic Microangiopathies

Blood, Sweat and Smears - Diagnosing Thrombotic Microangiopathies

Blood, Sweat and Smears - Hemophilia Genetic Testing

Dr. Brad Lewis discusses considerations for genetic testing when it comes to hemophilia and rare forms of von Willebrand disease.

Blood, Sweat and Smears - Heparin Induced Thrombocytopenia

Dr. Brad Lewis talks through how he thinks about Heparin Induced Thrombocytopenia (HIT) and when testing is called for. Dr. Lewis leverages his decades of clinical experience to help clinicians approach patients suspected of having HIT.