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Chaga Mushrooms have effects against cancer


CME in research from Showa University, Tokyo, reduced lung cancer tumors by 60 per cent in mice, and in metastatic disease the number of nodules reduced by 25 per cent (1). In particular, chaga mushroom extract restricted blood supply formation. The middle aged mice also experienced decreased body weight with the chaga infusions.


In a 2021 study (2) with breast cancer both in vitro and in vivo, Chaga Mushroom extract was shown to cause autophagy by activating and promoting the AMPK pathway while inhibiting the mTOR pathway. The in vivo studies showed that CME used every other day, restricted breast cancer tumor growth in mice.  Chaga mushrooms are already used in cancer treatment in South East Asia as a complementary therapy to boost the immune system during chemotherapy and radiotherapy.


The active anti-cancer ingredients appeared to be inotodiol and trametenolic acid both of which exhibited cytotoxic effects on a wide variety of cancer cells without interfering with the cytotoxic effects of any drug.


A 2015 Korean study (3) showed that another active compound in chaga could inhibit Colorectal cancer. Ergosterol peroxide inhibited cell proliferation and also suppressed  tumor formation by causing apoptosis, and inhibiting nuclear levels of β-catenin.


There is also 2008 research from Korea (Myung Ja-Youn et al.) in the Journal of Gastroenterology with liver cancer; and in 2009 by the same team in the Journal of Ethnopharmacology with melanoma.



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