013 - Shawn Wells – On Mitochondrial Health, Supplements, & Tribe

00:57 – Introducing today’s guest, Shawn Wells 

05:53 – Shawn breaks down the role of mitochondria its impact on energy 

07:14 – Insufficient Cellular Energy (ICE) states 

09:38 – Glycation, explained 

12:17 – Signs of accelerated glycation 

14:10 – The benefits of the supplement, Berberine

16:22 – The value of context 

17:53 – The importance of checking and modulating your blood sugar 

20:23 – How Barberry works 

22:09 – How chronic low-grade inflammation can affect our mitochondria

25:06 – Dr. Stephanie and Shawn discuss why it’s not ideal to rely on caffeine and other energy boosters that have negative side effects 

28:39 – Dr. Stephanie explains oxidative phosphorylation

29:25 – How keto works 

30:49 – Key differences between ketogenic diets and Standard American Diet 

39:41 – Digestive resistant starches 

45:39 – Benefits of being metabolically flexible 

51:22 – Shawn’s favorite foundational supplements 

55:11 – Dr. Stephanie and Shawn talk about the supplement NAD 

59:02 – The power of mitochondrial pathways 

1:02:21 – The value of recovery 

1:03:44 – Happiness 

1:06:50 – Sleep deprivation and social jetlag 

1:09:19 – Community and sex 

1:11:47 – Shawn answers a series of rapid-fire questions 

1:18:21 – Where listeners can follow Shawn 

1:18:59 – Dr. Stephanie thanks Shawn for joining the show 

1:19:23 – Where listeners can follow Dr. Stephanie and subscribe to her newsletter

TWEETABLE QUOTES

“What happens though, that’s so important that we’re finding out, why I say, ‘mito is the new keto,’ is that we are often in insufficient cellular energy states, which is an acronym called ICE. And, there’s something else that’s in neurological diseases, it’s a very similar idea called brain energy gap.” (07:14)  

“It’s [Berberine] been shown in studies to be as effective, if not more effective, than Metformin, which is known as an incredible glucose disposal agent.” (14:47)  

“One of the ways that keto works is that you’re not creating as much oxidation and you are using an alternate fuel source – ketones – and you are insulin-resistant, and you are in this insufficient cellular energy state, and you don’t have enough glucose readily available for substrate. That’s why keto is a miracle.” (29:34)  

“It’s a beautiful thing in terms of evolution that we could be by the ocean, we could be in the trees, we could be in a barren winter wasteland, we could be in whatever climate all over the world and find a food source. That’s incredible.” (46:53)  

“When we’re in an optimized state, when our mitochondria are functioning optimally, we’re not only anti-aging, anti-disease, pro-energy, but we’re able to deal with stress better.” (1:01:08)  

“I think happiness is a choice. Every day you can choose whether you’re happy or not, whether you’re positive or not.” (1:04:24)  

“I have amazing people like you [Dr. Stephanie] in my life because of the energy I’m putting out is coming back to me. And, it’s so important that yes you’ve been burned, yes you’ve been hurt, but don’t let that change what’s going out because that’s what’s going to come back.” (1:12:44)  

“Whatever you’re thinking right now is your weakness is actually probably your superpower. You’re hiding it away and it’s the thing you’re so blessed for that makes you unique. And, once you let it out, you’ll become so powerful.” (1:15:28)  

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