Understanding the Role Transcription Factors Play in Obesity

Obesity has nearly tripled worldwide since the 1970s. Consequently, a major health concern related to obesity is that excess fat can spill into organs such as the liver, which can lead to fatty liver disease or even liver cancer. Grant Barish, MD, assistant professor in the Division of Endocrinology, Metabolism and Molecular Medicine, explains his latest work examining metabolic switches to understand why metabolic disorders such as obesity occur and how they could be used as potential therapies.