In this Better Edge podcast episode, Edward M. Schaeffer, MD, PhD, chair and the Edmund Andrews Professor of Urology at Northwestern Medicine, discusses the PREVENT Randomized Trial (PReclude infection EVEnts with No prophylaxis Transperineal), a study in which he was co-primary investigator. The trial, funded by the National Cancer Institute, compared the outcomes of transperineal biopsy without antibiotic prophylaxis to transrectal biopsy with targeted prophylaxis.