Deconstruction of Rheumatoid Arthritis Synovium Defines Inflammatory Subtypes

In this Better Edge podcast, Harris Perlman, PhD, and Arthur Mandelin, MD, PhD, of Northwestern Medicine Rheumatology, discuss their participation and findings from a study that used multi-modal single-cell RNA-sequencing coupled with histology of synovial tissue from 79 donors to build single-cell atlas of rheumatoid arthritis synovial tissue. Dr. Perlman and Dr. Mandelin discuss using the findings of this study to propose a bench to bedside, then back to bench plan to individualize treatments and therapies for patients with RA.