Between the beginning of the COVID-19 pandemic and May 2022, more than 527 million cases of SARS-CoV-2 have been confirmed. COVID-19 represents an ongoing challenge to the field of neurology, as neurologic complications of the disease are leading to an increase in demand for both acute and long-term neurologic evaluation and management. Three experts from Northwestern Medicine Neurology — Igor J. Koralnik, MD, Eric M. Liotta, MD, and Edith L. Graham, MD — have been investigating the pathogenic mechanisms of acute and long-term COVID-19, as they may inform clinical evaluation and management. They discuss their guideline "Therapeutic Approaches to the Neurologic Manifestations of COVID-19," published in Neurotherapeutics in July 2022.