Success came quickly for Murdock with the release of her gold-selling debut LP, Shirley Murdock! ... on Elektra Records. After her initial hit, "No More," stormed the dance charts, the tender ballad "As We Lay" shot up to #5 on the Billboard R&B singles chart and also charted nicely on both the Top 40 adult contemporary and pop charts in 1986.

A chance meeting with Bishop T.D. Jakes at a post-service gathering at Murdock’s pastor’s home, led to her recording "The Lady, Her Lover, and Lord," on his Sacred Love Songs, project in 1999.  "I told Bishop Jakes that I always wanted to do a gospel CD, so when he launched his record label, Dexterity Sounds, he called me and said, "...here's your chance to do that CD.’"   The Home project received a warm embrace from the gospel world and reached #9 on the Billboard Top Gospel albums chart in 2002. It was a dream come true that Murdock feels may have never happened were it not for her secular career. "I never pursued a secular career," she testifies. "It came to me. It opened an opportunity for me to take the gospel into the secular arena in ways that many gospel artists cannot.