Wellness and fisetin

Episode 57: In this episode, host Angie Gust talks about senescent cells and fisetin.  When normal cells get too damaged (as in accumulating too much DNA damage), they could turn into cancer cells. To prevent this, these damaged cells change to where they cannot divide anymore, so in that way, they cannot become cancer cells. Rather, they became senescent cells.  A bad thing is that. these cells secrete substances that damage the healthy surrounding cells, contributing to aging.  Fisetin has been shown to be good at clearing out this senescent cells.  Now turning to the environment. The 2023 UN Climate Conference, COP28, concluded on December 13th. While some think it was an improvement over other conferences, others thought it did not go far enough and left loop holes. The deal calls for transitioning away from (not phasing out) fossil fuels  in energy systems, in a just, orderly and equitable manner ... so as to achieve net zero by 2050. There was an agreement to triple renewables and double energy efficiency by 2030. There is hope, but definitely more to be done.

References

Carbon Brief. https://www.carbonbrief.org/cop28-key-outcomes-agreed-at-the-un-climate-talks-in-dubai/

Children of the Earth. https://www.childrenoftheearth.org/seigelman.htm

IEA (2023), World Energy Outlook 2023, IEA, Paris https://www.iea.org/reports/world-energy-outlook-2023, License: CC BY 4.0 (report); CC BY NC SA 4.0 (Annex A)

Life Extension. Feb 2021. Fisetin: A Senolytic That Extends Life.https://www.lifeextension.asia/magazine/post/fisetin-a-senolytic-that-extends-life

Novos. https://novoslabs.co/causes-of-aging-senescent-cells/?gad_source=1&gclid=CjwKCAiAsIGrBhAAEiwAEzMlC_iEEf3Ylj76zw82sBSt2N5zk3OIqwLhsROkteGC5FQ5svuFTSkVVhoCBr8QAvD_BwE

Novos. Why do we age? Cellular senescence. https://novoslabs.com/causes-of-aging-senescent-cells/

Pakalolo. Nov 16, 2023. httphttps://www.dailykos.com/stories/2023/11/16/2206148/-The-World-Meteorological-Society-Climate-heating-gases-reach-record-highs://www.dailykos.com/stories/2023/11/16/2206148/-The-

Volcovici, V, Dickie, G, James, W. Dec 13, 2023. Nations strike deal at COP28 to transition away from fossil fuels. https://www.reuters.com/business/environment/countries-push-cop28-deal-fossil-fuels-talks-spill-into-overtime-2023-12-12/#:~:text=DUBAI%2C%20Dec%2013%20(Reuters),end%20of%20the%20oil%20age.

World-Meteorological-Society-Climate-heating-gases-reach-record-high?pm_campaign=front_page&pm_source=trending&pm_medium=web

Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28.