Sirtuins obtain a significant role in mitochondrial metabolism linked to caloric restriction and cancer. Dr Guerra. Authentic Biochemistry.26.02.21

Authentic Biochemistry

English - February 26, 2021 23:45 - 29 minutes - 27.5 MB - ★★★★★ - 10 ratings
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Previous Episode: Thermodynamics and regulation involving lipoic acid biochemistry of the classical 2-oxo acid dehydrogenase complexes. Dr Guerra 23.02.2021

Next Episode: Amino Acid Catabolism via Sirtuins Modulation and the Redirecting of Hepatic and Intestinal Intermediary Metabolism. Dr Guerra Authentic Biochemistry. 02 March 2021

SIRT5 causes deglutarylation and functional activation of glutamate dehydrogenase 1 which is essential to cellular glutaminolysis.Indeed, SIRT5 supports the anaplerotic transamination entry of glutamine and other amino acids as alpho ketoglutarate into the TCA cycle in malignant phenotypes of colorectal cancer via activation of the glutamate dehydrogenase1.

Sirt5 is known to regulate the activity of the urea cycle enzyme, carbamoyl phosphate synthase 1 (CPS1). SIRT5 mediated de-glutarylated CPS1 is elevated in activity to maintain urea cycle competency during active amino acid incorporation into the bioenergetic machinery thus promoting the potentiation of tumorigenesis.

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