AMiNDR: A Month in Neurodegenerative Disease Research artwork

AMiNDR: A Month in Neurodegenerative Disease Research

347 episodes - English - Latest episode: about 1 month ago -

This is a podcast made by scientists for scientists, to help you save time so you can conduct better research. For a given month, we sort the abstracts of the latest primary research articles on Alzheimer's disease into separate categories. We then summarize them for you to enjoy on the bus, on your jog, or in the lab. We hope you find our podcast useful and accessible.

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Episodes

338 - Interview with Joseph Liang - Navigating The Journey To (And Through) Graduate School

February 20, 2024 03:35 - 24 minutes - 22.6 MB

Another special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school. Tune in to learn what he has to say about getting into graduate school, and how his perspective on the journey has changed since he's started! W...

337 - Prevention & Intervention Strategies for AD

February 14, 2024 02:57 - 29 minutes - 27 MB

In today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy!   Cognitive and Social Factors (2:26) Lifestyle interventions (13:40) Stimulation Techniques (19:20) --------------------------------------------------------------  You can find the bibliography for this e...

336 - Treatments Targeting Cholinergic Neurotransmission in AD

February 06, 2024 02:33 - 29 minutes - 26.9 MB

Join us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barrier. Enjoy!   Papers evaluating synthesized compounds (2:00)   Papers targeting AchE (10:45) --------------------------------------------------...

335 - A Conversation with Gina Martin: Bringing Visual Awareness to Dementia

January 29, 2024 21:52 - 52 minutes - 47.6 MB

As we get back up to speed on our regular episodes, we thought we'd treat you (and ourselves) to something out of the ordinary: a conversation on how visual storytelling can shape how we think - and feel - about Alzheimer's disease. Host Naila Kuhlmann had the pleasure of interviewing Gina Martin, who founded the Bob and Diane Fund to support and promote visual storytelling about Alzheimer's and dementia. Tune in to get the backstory on the fund, an auditory glimpse at the work of this year'...

334 -Treatments Targeting Neuroprotection in Alzheimer's Disease

January 23, 2024 05:11 - 27 minutes - 24.8 MB

Hello listeners, it’s been a while since we last released an episode but we are back with another series here at AMiNDR bringing you a synopsis of publications on Alzheimer’s disease (AD) research on various topics that were released in November of 2023. In this episode, Anusha takes you through 11 papers testing potential neuroprotective agents for AD treatment. You’ll hear about naturally and pharmaceutically-derived compounds as well as strategies that exploit cell-endogenous processes fo...

333 - Cognitive & Behavioural Changes in Alzheimer's Disease: February 2023

May 08, 2023 19:00 - 19 minutes - 18 MB

If you’re interested in hearing about the impact of hearing aids on quality of life in AD patients, or how having a stable life partner can slow down the progression of dementia, tune in to this episode on the latest in cognitive and behavioural research in Alzheimer's disease! Judy will cover 9 papers on sleep, depressive symptoms and sensory processing, all published in February 2023. This is one you don't want to miss!   Sections in this episode:   Sleep (2:42)   Depressive Symptoms (8...

332 - Prevention & Intervention Strategies for Alzheimer's Disease: February 2023

May 03, 2023 15:00 - 27 minutes - 25.1 MB

In today's episode, Naila provides you with an overview of 10 paper published in February 2023, on non-pharmacological therapies for Alzheimer's disease. You'll learn about a virtual reality intervention targeting anxiety, the signaling pathways underlying the potential benefits of acupuncture, the challenges of implementing new interventions, and what spectral light flicker means. Happy listening!   Sections in this episode:   Psychological Interventions (1:37)   Physical Activity (7:26)...

331 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2023

May 02, 2023 00:19 - 23 minutes - 21.3 MB

This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appetite.   Sections in this episode:   Targeting Specific Neuroprotective Pathways (3:39)   Targeting Neuroprotection Broadly (13.21)  -----------...

330 - Vascular Changes in Alzheimer's Disease: January 2023

April 11, 2023 14:54 - 40 minutes - 36.8 MB

Elyn's back with more insight from the field on how blood vessel health impacts brain health. Tune in for a journey through mechanisms underlying increased risk from "vascular risk factors" like hypertension, diabetes, and atrial fibrillation, lots of neuroimaging studies providing clinical insights, and several interesting novel therapeutic avenues. If you weren't already convinced that the vasculature is relevant in the context of AD, you sure will be after this episode!   Sections in thi...

329 - Treatments Targeting Neurotransmission in Alzheimer's Disease: January 2023

April 07, 2023 07:09 - 22 minutes - 20.5 MB

This episode covers some papers from January 2023 on treatments focused on repairing the neurotransmitter imbalance in Alzheimer's disease. We hope you enjoy listening as Christy summarizes this exciting research—from the discovery of new therapeutics to the synthesis of drugs.  Sections in this episode: Drug Screening (3:37) New Drugs (7:00) Synthesized Drugs (13:35) --------------------------------------------------------------  To find the numbered bibliography with all the papers c...

328 - Functional Connectivity & Imaging in Alzheimer's Disease: January 2023

April 04, 2023 02:37 - 32 minutes - 29.7 MB

In today’s episode of AMiNDR, Ellen will tell you all about the functional connectivity of different networks in the brain, and changes to brain structure and volume in Alzheimer’s disease. This includes how these changes in the brain relate to cognitive changes, behavioural symptoms, and other neuropathological markers. There are many fascinating studies to hear about today!   Sections in this episode:   Functional Connectivity (4:26)   Excitation/Inhibition Balance & Neuronal Hyperactiv...

327 - Prevention & Intervention Strategies for Alzheimer's Disease: January 2023

March 30, 2023 18:43 - 30 minutes - 27.5 MB

Naila covers 11 papers from January 2023, with a focus on a variety of stimulation techniques. You'll get a smattering of new research from humans to mice to flies, and from brain imaging to computer simulations to molecular mechanisms. Enjoy!   Sections in this episode:   Complementary therapies (2:55)   Current and magnetic stimulation (7:25)   Electroacupuncture (14:30)   Other stimulation techniques (22:15)  Other (25:52)  ----------------------------------------------------------...

326 - Cognitive & Behavioural Changes in Alzheimer's Disease: January 2023

March 28, 2023 22:39 - 25 minutes - 23 MB

We’ve got a whole variety of studies in this January 2023 episode, spanning from sensory processing, to sleep, and even to depressive symptoms. Tune in to learn more about the latest in cognitive and behavioural changes in Alzheimer's disease!   Sections in this episode:   Sensory Processing (2:28)   Sleep (7:30)   Balance (14:14)   Depression (17:00)   Other (20:40)  --------------------------------------------------------------  To find the numbered bibliography with all the papers...

325 - Treatments Targeting Neuroprotection in Alzheimer's Disease: January 2023

March 23, 2023 04:18 - 39 minutes - 36.6 MB

In this episode, we’ll be covering papers that were released in January 2023 that target neuronal and synaptic protection in Alzheimer’s Disease. If you’re interested in the preclinical testing of novel therapeutics and delivery methods, this is the episode for you!   Sections in this episode:   Novel Therapeutics Targeting Neuroprotection (4:53)   Novel Delivery Methods Targeting Neuroprotection (8:49)   Targeting Synaptic Pathology (16:42)   Targeting BDNF Activation (23:18)  We at A...

324 - Synaptic Transmission in Alzheimer's Disease: January 2023

March 21, 2023 03:40 - 25 minutes - 23.6 MB

We are diving in to all things neurotransmitters and synaptic signaling to kick off the January 2023 series. You'll hear about dopamine, noradrenaline, prion proteins, a new 3D cell culture model, and more, in today's episode. Enjoy!   Sections in this episode:   Monoamine Neurotransmitters (3:50)   Glutamate (9:18)   Acetylcholine (15:51)   Synaptic Proteins (17:43)   New 3D Culture Method (21:32)  --------------------------------------------------------------  To find the numbered ...

323 - The Immune System & Glia in Alzheimer's Disease Part 1: November 2022

March 09, 2023 01:00 - 27 minutes - 24.7 MB

Welcome our new host, Anelya, who covers 12 papers on the role of immune system and glia in Alzheimer’s disease. The first half of this episode will focus on potential targets for the treatment of Alzheimer’s disease, followed by the disease-associated inflammatory mechanisms. Part 2 will be released as a bibliography. We hope you find this episode interesting!   Sections in this episode:   Potential Therapeutic Agents (2:28)   Disease-Associated Neuroinflammatory Mechanisms (14:08)  ---...

322 - Functional Connectivity & Imaging in Alzheimer's Disease: November 2022

March 07, 2023 05:05 - 21 minutes - 19.7 MB

Ellen brings you summaries of 8 abstracts from November 2022, all about functional connectivity and imaging in the context of Alzheimer's disease. There are a variety of brain regions covered in today's episode, including cortical regions, subcortical structures, and the hippocampus. Spanning studies in both humans and animals, this episode is sure to have something of interest to you and your research!   Sections in this episode:   Cortical regions (3:39)   Subcortical forebrain regions ...

321 - Prevention & Intervention Strategies for Alzheimer's Disease: November 2022

February 28, 2023 05:08 - 48 minutes - 44.1 MB

For today's episode, Naila is back to take you through 20 papers on prevention and intervention strategies in Alzheimer's. You'll be treated to the latest on mindfulness and meditation, the default mode network's involvement in Alzheimer's, strategies for assessing and optimizing therapies, stimulation techniques and more. Enjoy!   Sections in this episode:   Innovation assessment (3:08)   Cognitive Training (6:36)   Mindfulness and Movement (13:39)   Diet (26:00)   Sensory Stimulation...

320 - Treatments Targeting Neuroprotection in Alzheimer's Disease: November 2022

February 23, 2023 03:00 - 25 minutes - 23.6 MB

In this episode, Anusha guides you through 11 papers that were published in November of 2022. These papers study the efficacy of treatments targeting neuroprotection in Alzheimer's Disease models. Tune in if you want to be on the cutting edge of drug discovery and development in the field of AD.   Sections in this episode:   Drug Discovery and Development of Novel Therapeutics (3:49)   Testing Existing Compounds (17:27)  --------------------------------------------------------------  To...

319 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: November 2022

February 21, 2023 04:00 - 20 minutes - 18.8 MB

Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don’t want to miss this one!   Sections in this episode:  Behavioural Changes (3:30)  Learning History (13:45)  Depressive Symptoms (15:32)  ------------------------...

318 - Synaptic Transmission in Alzheimer's Disease: November 2022

February 16, 2023 03:03 - 26 minutes - 24.3 MB

Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode!   Sections in this episode:   Glutamate and Acetylcholine (4:01)   GABA neurons (10:52)   Neuron Excitability (12:15)   Synaptic Proteins (15:10)   Neuro-Immuno-Endocrine System (21:45)  --------------------------------------------------------------  To find the nu...

317 - Functional Connectivity & Imaging in Alzheimer's Disease: October 2022

January 27, 2023 21:00 - 23 minutes - 21.8 MB

Today, we talk all about neuroimaging, with 7 papers that use various imaging modalities in humans, animals, and computational modeling, to study how the brain changes in Alzheimer’s disease. Tune in to learn more!   Sections in this episode:   Hippocampus (3:50)   Hypothalamus (8:15)   Cortical regions (10:29)   Nucleus basalis (15:57)   Pineal gland (18:40)  --------------------------------------------------------------  To find the numbered bibliography with all the papers covered...

316 - Treatments Targeting Neuroprotection in Alzheimer's Disease: October 2022

January 24, 2023 04:30 - 31 minutes - 28.7 MB

Anusha brings you another episode of AMiNDR featuring literature published in October 2022. In this episode, you'll hear 12 papers that converge on the topic of treatments that target neurotoxicity. This episode is poised to leave you feeling hopeful about the various treatment avenues to be pursued so be sure to tune in!   Sections in this episode:   Targeting Neurotoxicity in vitro (3:53)   Invertebrate models of AD (8:41)   Transgenic AD models (14:48)   Other AD models (22:47)  ---...

315 - Cognitive and Behavioural Changes in Alzheimer's Disease: October 2022

January 19, 2023 04:49 - 26 minutes - 24.6 MB

In today's episode, there's a big focus on sleep in Alzheimer's disease, as well as other clinical and pharmacological studies that dive into the cognitive and behavioural deficits. We even have one paper that looks into character strengths in AD, so definitely join Judy and follow along in this unique episode from our October 2022 series!   Sections in this episode:   Sleep (2:53)   Behavioural changes in rodent models (7:00)   Behavioural changes in humans (10:02)   Cognitive changes ...

314 - Vascular Changes in Alzheimer's Disease: October 2022

January 17, 2023 04:22 - 30 minutes - 27.9 MB

In this episode, Elyn takes you through 13 papers from October 2022 published on vascular contributions to Alzheimer disease. It's quite the journey through mechanistic mouse studies, neuroimaging studies, and a few studies assessing treatments targeting the vasculature, which all paint a pretty convincing picture of the importance of the cerebrovasculature in brain health. Tune in to learn more about the glymphatic system, consequences of amyloid deposition on the vasculature, and a clinica...

313 - Synaptic Transmission in Alzheimer's Disease: October 2022

January 12, 2023 02:01 - 13 minutes - 12.5 MB

Kick off the new year with Ellen, who tells you all about synaptic transmission in Alzheimer's disease in this episode. You'll hear about 5 papers published in October of 2022 on synaptic transmission, ranging from research on whole brain networks all the way down to individual proteins.  --------------------------------------------------------------  To access the numbered bibliography for this episode, click here, or use the link below: https://drive.google.com/file/d/1sIxUDc8NrG6HAXL9i...

312 - Prevention & Intervention Strategies for Alzheimer's Disease: August 2022

December 29, 2022 05:49 - 37 minutes - 34 MB

We have one last episode for you to wrap up 2022! In this episode, Naila will guide you through 11 papers published in August 2022, covering a range of way researchers are working on preventing or treating aspects of Alzheimer's disease through non-pharmacological therapies. You'll hear about cognitive training tools, the effects of disrupting circadian rhythms on metabolism and Alzheimer's, and on vagal nerve stimulation for treating neuropsychiatric symptoms related to AD. You may also hea...

311 - Understanding APOE: August 2022

December 22, 2022 06:41 - 28 minutes - 25.8 MB

In this month's episode of AMiNDR, Cassi recaps papers on APOE published in August 2022. Cassi just defended her dissertation where she studied immunometabolism in the context of APOE. She starts with cells, moves to mice, and finishes with human research studies.  --------------------------------------------------------------  To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below: https://drive.google.com/file/d/11pGVGJGUWfPNAqJ-...

310 - Cognitive and Behavioural Changes in Alzheimer's Disease: August 2022

December 15, 2022 19:00 - 20 minutes - 18.8 MB

Today, we have papers on behavioural and cognitive changes in Alzheimer’s disease. We’ve got our usual sections such as rodent models and sleep, but we also have some new topics, including cognitive reserve and even a paper on virtual reality. You’re in for a treat! Sections in this episode:   Behavioural Changes (2:28)   Cognitive Changes (11:10)   --------------------------------------------------------------  To access the folder with ALL our bibliographies, follow this link (it will...

309 - Vascular Changes in Alzheimer's Disease: August 2022

December 13, 2022 05:53 - 27 minutes - 25.2 MB

After a bit of a break, Elyn is excited to be back with the latest in the field of vascular contributions to Alzheimer disease. With the current (and constant) controversy in the field about targeting amyloid as a disease-modifying therapy, perhaps it's time we turned to a new target: the vasculature. Tune in for an overview of papers published in August 2022, including lots of nitric oxide signalling, animal model characterization, white matter hyperintensities and their relevant associatio...

308 - Synaptic Transmission in Alzheimer's Disease: August 2022

December 08, 2022 04:54 - 16 minutes - 15.4 MB

To kick off our series on August papers, we will talk all about different ways that synaptic transmission may be affected in Alzheimer's disease, with 6 research papers that use either cell models, animal models, or human patients. Stay tuned!   Sections in this episode:   Cortical signaling in rodent models (3:15)   New AD models (8:32)   Biomarkers of neural dysfunction in humans (9:24)   --------------------------------------------------------------  To find the numbered bibliograph...

307 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: July 2022

November 04, 2022 02:40 - 23 minutes - 21.4 MB

In Part 2 of Cognitive and Behavioural Changes, Naila covers 8 papers on neuropsychiatric, social and cognitive symptoms linked to Alzheimer's disease, and their implications for diagnosis and disease management. You'll learn about the links between AD and depression, the importance of social networks, and machine learning methods for identifying important lifestyle information from clinical notes. Enjoy!   Neuropsychiatric Changes (2:11) Cognitive Changes (10:25) Statistics and Machine ...

306 - Prevention and Intervention Strategies for Alzheimer's Disease: July 2022

November 01, 2022 07:09 - 45 minutes - 41.9 MB

In this episode, Naila will guide you through 14 papers on potential neuroprotective factors to mitigate the risk of Alzheimer's disease, non-pharmacological interventions that could directly target Alzheimer's pathology, and strategies for symptom management. You'll hear about the role of embodiment in memory, light therapy technologies, the role of diet, and a few molecular pathways underlying the effects of exercise and neuronal stimulation. Sections in this episode: Cognitive and affec...

305 - Treatments Targeting Neuroprotection in Alzheimer's Disease: July 2022

October 27, 2022 05:24 - 26 minutes - 24.5 MB

This is an episode all about targeting synaptic and neuronal heath in Alzheimer's disease. Anusha will cover in silico, in vitro, and in vivo studies of candidate compounds that target neuroprotection and neurogenesis. Be sure to check out this paper to stay up to day on the latest preclinical therapeutics being tested.   Sections in this episode:   In silico and treatment development (3:24)   Targeting Neurogenesis (7:07)   Targeting Neuroprotection (12:00)  ---------------------------...

304 - Understanding APOE: July 2022

October 20, 2022 03:49 - 25 minutes - 23 MB

In this episode exploring the effect of allelic variation of APOE, we review abstracts from large human GWAS studies all the way down to new mouse models expressing the human ApoE proteins. There are some particularly interesting abstracts on protection from cognitive decline despite having a risk allele for Alzheimer's disease. These are great studies to open the door for future research in this field!   Sections in this episode:   Human Research (2:58)   Mice Research (15:53)  --------...

303 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: July 2022

October 17, 2022 21:00 - 14 minutes - 13.5 MB

Part 1 of our cognitive and behavioural changes category will focus on papers that explore behavioural and sensory processing deficits in AD. Topics range from motor impairments to visual and olfactory processing in both human patients and mouse models of AD. If you're curious about how AD patients process the facial expression of pain, then this is the episode for you!   Sections in this episode:   Behavioural Changes (2:39)   Visual Processing (6:23)   Olfaction (9:20)   Pain and Emot...

302 - Vascular Changes in Alzheimer's Disease: July 2022

October 13, 2022 03:00 - 29 minutes - 26.9 MB

Elyn is back to discuss the latest research on vascular contributions to Alzheimer disease! Tune in to hear about proteomic changes with amyloid deposition in the vasculature, new therapeutic avenues, and a more detailed account of the perivascular space. If you're interested in factors beyond amyloid and tau in the Alzheimer disease pathology, this is a great place to start!   Sections in this episode:   Cardiovascular Risk Factors (3:45)   White Matter Hyperintensities (8:51)   Cerebra...

301 - Synaptic Transmission in Alzheimer's Disease: July 2022

October 12, 2022 21:28 - 30 minutes - 28.2 MB

We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what you’re interested in, stay tuned!   Sections in this episode:   Special Mention of Blots in a Field? (3:39)   Network Dysfunction (4:53)   Syn...

300 - Prevention and Intervention Strategies for Alzheimer's Disease: June 2022

September 17, 2022 04:59 - 41 minutes - 37.8 MB

Today's episode includes 15 papers on non-pharmacological treatments and complementary therapies for AD. Naila will take you through research published in June 2022 on an array of topics including olfactory training, beer, choir participation, light therapy, and transcranial magnetic stimulation. You'll be treated to research on both the human and animal level, with a special focus on targeting neuroinflammation and brain connectivity!   Sections in this episode:   Cognitive Training and C...

299 - Cognitive Assessment in Alzheimer's Disease Part 2: June 2022

September 15, 2022 18:41 - 29 minutes - 27.1 MB

We promised you we would be back with more on clinical assessment for Alzheimer’s disease, and here we are to deliver.   Stick around to hear about papers published in June 2022 on validating variations of the Montreal Cognitive Assessment, tracking Activities of Daily living, and digital tools for assessing cognition. Our harvest yielded 7 abstracts, all presented in this episode!   Sections in this episode:   Combinign Multiple Neurocognitive Domains (7.00)   Activities of Daily Living...

298 - Understanding APOE and Alzheimer's Disease: June 2022

September 08, 2022 06:13 - 20 minutes - 18.7 MB

Approximately, one in every five people you know, has a copy of the largest genetic risk allele for late-onset Alzheimer's disease called apolipoprotein E4 (APOE). In this episode, Cassi discusses papers from June 2022 about APOE and covers human subjects research, pathology related to E4 risk, and mechanisms.   Sections in this episode:   Human Subjects Research (2:52)   AD Pathology (11:19)   Mechanism (15:12)   Targeting Memory Impairment with Genetic Manipulation (10:51)   Targetin...

297 - Genetic Insights for Alzheimer's Disease: June 2022

September 06, 2022 05:27 - 32 minutes - 29.9 MB

In this episode, Joseph covers papers published in June 2022 on GWAS studies, transcriptomics, genetic and genomic studies and the like on Alzheimer’s disease. Stay tuned!   Sections in this episode:   Genetic & Disease Overlaps (2:15)   RNA & Transcriptomics (5:10)   Genetic Testing (10:25)   GWAS Studies (15:24)   Specific Genes (21:04)   Extra (28:55)  --------------------------------------------------------------  To find the numbered bibliography with all the papers covered in ...

296 - Treatments Targeting Neuroprotection in Alzheimer's Disease: June 2022

September 01, 2022 05:41 - 25 minutes - 23.2 MB

Anusha brings you 12 papers today on the development of treatments that target neuroprotection in Alzheimer's disease. This includes a range of research models, from in silico and drug discovery studies, to rodent models of AD. Enjoy!   Sections in this episode:   In Silico and Drug Discovery Studies (2:27)   Testing Phytochemicals in AD Rodent Models (7:29)  --------------------------------------------------------------  To find the numbered bibliography with all the papers covered in ...

295 - Cognitive and Behavioural Changes in Alzheimer's Disease: June 2022

August 29, 2022 17:11 - 24 minutes - 22.7 MB

This episode contains a whole range of topics in cognitive and behavioural changes in AD! Tune in as Judy covers a variety of papers published in June 2022, spanning from from sensory processing in mouse models to antidepressants in human patients. There's bound to be something that piques your interest!   Sections in this episode:   Studies Using Mouse Models (2:03)   Sensory Processing (7:15)   Behavioural Changes in AD (13:08)   Cognitive Changes in AD (15:49)   Neuropsychiatric Cha...

294 - Cognitive Assessment in Alzheimer's Disease Part 1: June 2022

August 26, 2022 19:00 - 35 minutes - 32.2 MB

You are here, with us, right now, about to get the updates you eagerly wait for every month in Alzheimer’s disease research. A whole episode dedicated to assessing neurocognitive domains for screening and diagnostics. Learning and memory? Executive function? Perceptual and motor skills? You got it! 7 abstracts published in June 2022, nicely packaged for you in this podcast.   Sections in this episode:   Learning & Memory (7:41)   Executive Function (26:18)   Perceptual-Motor  (28:25)  -...

293 - Vascular Changes in Alzheimer's Disease: June 2022

August 24, 2022 19:00 - 28 minutes - 25.7 MB

Ever thought there was more to Alzheimer disease than the plaques and tangles? You've come to the right place. Join Elyn for a guide through the latest research on vascular contributions to Alzheimer disease. June 2022 brought lots of new insight into how vascular hallmarks interact with the classic AD hallmarks to influence cognition, emphasis on vascular pathology in familial Alzheimer disease, and so much more. Tune in for a riveting episode!   Sections in this episode:   Cardiovascular...

292 - Synaptic Transmission in Alzheimer's Disease: June 2022

August 23, 2022 04:38 - 17 minutes - 16.4 MB

We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode is a great place to start!   Sections in this episode:   Changes to neurotransmission and neuronal excitability (2.44)   Changes to movement/lea...

291 - Vascular Contributions to Alzheimer's Disease: May 2022

August 01, 2022 19:00 - 20 minutes - 19 MB

Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis!   Clinical Studies (3:53) Preclinical Studies/Methology (12:41)    --------------------------------------------------------------   To find the numbered bibliography with all the papers covered in this episode, click here, or use the lin...

290 - Treatments Targeting Neuroprotection in Alzheimer's Disease: May 2022

July 29, 2022 19:00 - 22 minutes - 20.9 MB

Anusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopeful about future therapeutic directions!   Drug Discovery/Development (1:52) Targeting Neuronal Functions (9:19) Targeting Neuroprotection (14:2...

289 - Cognitive and Behavioural Changes in Alzheimer's Disease: May 2022

July 27, 2022 19:00 - 25 minutes - 23.1 MB

In this exciting episode, Judy goes over papers published in May 2022 on the latest research involving cognitive, behavioural and clinical changes in AD. Subjects include sensory processing, mouse models, sleep, and many more!     Sensory Processing (1:45) Mouse Models (5:44) Clinical Treatments (8:34) Sleep (12:59) Other (17:29)   --------------------------------------------------------------   To find the numbered bibliography with all the papers covered in this episode, click he...

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