E490 Theonie Anastassiadis, Co-Founder and Chief Innovation Officer & Stephen Eichhorn, Principal Scientist at Alltrna

Today's guests are Theonie Anastassiadis, Co-Founder and Chief Innovation Officer & Stephen Eichhorn, Principal Scientist at Alltrna. Founded in 2018, Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. The company has an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.

Alltrna have successfully applied machine learning to reveal the unique language of tRNA biology. This language is larger than the number of atoms in the universe and turns powerful biology into programmable medicines. Their first-in-field platform integrates learnings across tRNA biology and the modality space to unlock tRNA’s full therapeutic potential and design tRNA oligos with desired therapeutic properties.

In today's episode, Theonie and Stephen talk about:

Their background and journey to now,

An overview of Flagship Pioneering,

How Alltrna are harnessing tRNA biology for therapeutic medicines,

Examples of how their work will improve treatment for patients,

The role of AI and Data Science in their platform,

What the near future holds for Alltrna,

An insight into the team and working culture,

What makes Alltrna a great place to work