Adverse Reactions
23 episodes - English - Latest episode: 9 months ago - ★★★★★ - 14 ratingsAn interview podcast bringing you the people and stories behind the science of how biological, physical, and chemical agents may cause adverse reactions to public, animal, and environmental health. This podcast is presented by the Society of Toxicology (SOT) and hosted by SOT members Anne Chappelle and David Faulkner.
About Anne
After graduating from the University of Delaware with a BS in biology in 1991, Anne Chappelle accidentally found her calling when she worked a gap year in an industrial toxicology laboratory. As it turned out, toxicology was the perfect marriage of protecting both human health and the environment. She then went on to receive her PhD in pharmacology and toxicology from the (now) University of the Sciences in Philadelphia in 1997, focusing on upper respiratory tract toxicity.
For the last 20+ years, as a toxicologist and risk assessment expert for the chemical industry, Anne has been thrilled to not work in a laboratory anymore. Along the way, she has added a few more titles: spouse; DABT; Principal of Chappelle Toxicology Consulting, LLC; occasional blogger at My Toxic Life; and most life changing (and expensive): Mom. She is thrilled to be partnered with David to add podcast co-host to the list because it gives her the opportunity to “channel my inner Terry Gross.”
About David
David Faulkner’s interest in science started at age five with a few Bill Nye the Science Guy VHS tapes and hasn’t diminished since. A lifelong artist and science fan, David has worked in nearly every mass communication medium to share his love of science with the world. Now, as an early career toxicologist, David is living out his dream of co-hosting a science podcast! With a budget! And a producer! And super cool guests! And an awesome co-host! David thinks Bill would be proud.
David attended the University of Michigan, where he completed a BS in microbiology, a BA in English language (emphasis in creative writing), and an MPH in environmental health sciences, and the University of California Berkeley, where he completed a PhD in molecular toxicology under the supervision of Dr. Chris Vulpe. He has held postdoctoral appointments at the Berkeley Center for Green Chemistry and the Lawrence Berkeley National Laboratory and just started a new position as a toxicological risk assessor. He also is a full-time parent to two adorable purple velvet plants: Planthony Bourdain and Marie Planthoinette.
Disclaimer
The viewpoints and information presented in Adverse Reactions represent those of the participating individuals. Although the Society of Toxicology holds the copyright to the production, it does not vet or review the information presented nor does presenting and distributing the Adverse Reactions podcast represent any proposal or endorsement of any position by the Society.
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Episodes
The Intersection of Toxicology, Environmental Health Law, and Justice
August 03, 2023 12:00 - 31 minutes - 21.5 MBAs the foremost experts on the effects of chemicals, biological substances, and more, toxicologists are key contributors to health regulation and laws. Law Professor and lawyer Claudia Polsky, University of California Berkeley, discusses how science can influence environmental health law, as well as environmental justice, with co-hosts Anne Chappelle and David Faulkner and reveals legal gaps in protecting public health. About the Guest Claudia Polsky, JD, MAS, is a Clinical Professor of Law...
Pitfalls in Pharmaceutical Production: Protecting the Actual Drug Makers
July 27, 2023 12:00 - 23 minutes - 16.2 MBWhile pharmaceuticals provide positive benefits for patients, what about workers that may be exposed during production? Elizabeth M. Vancza, Merck & Co. Inc., reveals to co-hosts Anne Chappelle and David Faulkner the role of occupational toxicologists in understanding the exposure risks of pharmaceuticals, chemicals, and other substances that may affect worker health, as well as how to protect them from these exposures. About the Guest Elizabeth M. Vancza, PhD, DABT, is currently an Associa...
The Big Picture of Small Things: Nanotoxicology
July 20, 2023 12:00 - 30 minutes - 20.8 MBNanoparticles are manmade fibers, particulates, and other objects that are so small that when inhaled, they can escape the lungs and enter other body systems. Timothy Nurkiewicz, West Virginia University, studies the effects of these and other particulars. He discusses his inhalation and nanotoxicology research, as well as work with the National Guard on developing facemasks to protect against airborne diseases, with co-hosts Anne Chappelle and David Faulkner. About the Guest Timothy R. Nur...
Tox in the Family: Generational Exposure and DDT
July 13, 2023 12:00 - 25 minutes - 17.2 MBBlood samples and health records for 15,000 pregnancies provides a wealth of scientific data. Add samples and records from the resultant children and grandchildren, and you have an invaluable cohort with which you can study the long-term results of events that occur during pregnancy. Barbara Cohn with the Public Health Institute is the Director of such a cohort and discusses it with co-hosts Anne Chappelle and David Faulkner, including what she and colleagues have discovered about the genera...
Bringing Cohorts in Cahoots with Lab Science
July 06, 2023 12:00 - 31 minutes - 21.4 MBThe fields of epidemiology and toxicology sometimes find themselves at odds, but Gradient’s Julie Goodman, an epidemiologist and toxicologist, shares how the two disciplines can complement each other to evaluate public health risks. Dr. Goodman also dives into the finer points of systemic reviews and meta-analyses in her conversation with co-hosts Anne Chappelle and David Faulkner. About the Guest Julie E. Goodman, PhD, DABT, FACE, ATS, is an epidemiologist and board-certified toxicologist ...
Estradiol Complicates Everything: Toxicology across the Gender Spectrum
June 29, 2023 12:00 - 28 minutes - 19.6 MBWhen it comes to hormones, everyone has them all, but their levels are where things get interesting. How chemicals affect estrogen signaling in the brain is the research focus of Troy Roepke, Rutgers, who talks to co-hosts Anne Chappelle and David Faulkner about how gender is not easily defined biologically, what it is like to be a “fabulously queer” professor, and how science can better serve the LGBTQ+ and other marginalized communities. About the Guest Troy Roepke, PhD, is an Associate P...
Up in Smoke: Where Cannabis Meets the Immune System
June 22, 2023 12:00 - 33 minutes - 23.4 MBSince the discovery of cannabinoid receptors in the mid-1990s, researchers have been trying to determine their role and how they affect the immune system. Barbara Kaplan, Mississippi State University, discusses research in this area with co-hosts Anne Chappelle and David Faulkner and also shares what scientists are discovering about CBD, vaping, THC, and more. About the Guest Barbara Kaplan, PhD, is an Associate Professor in the Center for Environmental Health Sciences in the College of Vet...
Wildfire Smoke Isn’t Monkey Business
May 05, 2022 12:00 - 26 minutes - 18.5 MBBecause of natural exposure to wildfire smoke, nonhuman primates have provided an increased understanding of the long-term effects of smoke inhalation during infancy, shares Lisa Miller, University of California Davis (UC Davis). Dr. Miller also discusses with co-hosts Anne Chappelle and David Faulkner the importance of animal models in human health research and how nonhuman primates can be good models for vaccine testing, as was the case with COVID-19. About the Guest Lisa A. Miller, Ph...
Sweating It Out: Exercise versus Toxic Exposures
April 28, 2022 12:00 - 25 minutes - 17.4 MBWith nonalcoholic fatty liver disease affecting nearly a third of the US population, Luma Melo, University of Pittsburgh, describes how mouse studies have shown that low-impact exercise can help reverse liver damage. Dr. Melo also shares with co-hosts Anne Chappelle and David Faulkner how research funding works in her native Brazil and the role of Brazilian women in toxicology. About the Guest Luma Melo, PhD, University of Pittsburgh, started her scientific career in her native Brazil, e...
Anthropogenic Ghosts on the Coast
April 21, 2022 12:00 - 26 minutes - 18.4 MBWhile no longer national news, the Deepwater Horizon oil spill is still impacting the ecological health of the Gulf of Mexico and the livelihoods of the communities that rely upon the gulf’s aquatic life, as Robert “Joe” Griffitt of the University of Southern Mississippi reveals. Dr. Griffitt and co-hosts Anne Chappelle and David Faulkner discuss how ecotoxicology is both an applied and a basic science, as well as how scientific discovery is not always a linear process. About the Guest R...
Lions and Vultures and Tox, Oh My
April 14, 2022 12:00 - 29 minutes - 20.3 MBHow human activity, chemical exposures, and environmental factors combine to contribute to wildlife population declines is at the forefront of the research by Dr. Caroline Moore and other teams at the San Diego Zoo Wildlife Alliance. Dr. Moore unravels the role of toxicology in wildlife conservation with co-hosts Anne Chappelle and David Faulkner. About the Guest Caroline Moore, PhD, DVM, serves the San Diego Zoo Wildlife Alliance as a Scientist in Disease Investigations. In this role, s...
The Delicious World of Food Safety
April 07, 2022 12:00 - 26 minutes - 18.4 MBEven chocolate companies and wineries need toxicologists. Alexandria G. Lau, ToxStrategies Inc., has worked for both and shares her experiences with co-hosts Anne Chappelle and David Faulkner. They also discuss the research and development that goes into new food products and how toxicologists play a role in food safety. About the Guest Alexandria G. Lau, PhD, DABT, ToxStrategies Inc., is a toxicologist with a decade of experience in the food and beverage industry. She has extensive knowled...
Heat Stressed: Biostats and Public Health
March 31, 2022 12:00 - 25 minutes - 17.7 MBBiostatistics or data science for public health—whatever you choose to call it—informs understanding of the health and environmental impacts of exposures. Emory University’s Howard Chang discusses with co-hosts Anne Chappelle and David Faulkner the intricacies of interpreting data, the controversial P value, and the team science involved in studying public health challenges. About the Guest Howard Chang, PhD, is a Professor in the Emory University Rollins School of Public Health Departme...
The Life-Giving Properties of Liquid Gold
March 24, 2022 12:00 - 31 minutes - 22 MBWith limited existing research on the effects of medications and exposures on lactation, Christina D. Chambers, University of California San Diego, shares work underway to better assess risks and benefits for mom and baby. Co-hosts Anne Chappelle and David Faulkner also discuss with Dr. Chambers the tricky roles of epidemiology and observational studies. About the Guest Christina D. Chambers, PhD, MPH, is a Professor in the Department of Pediatrics and the Department of Family and Preven...
Toxicology Is a Wise Choice: One Health, Many Ecosystems
March 17, 2022 12:00 - 24 minutes - 16.6 MBStudying the effects of metals in whales and alligators, among other species, can offer immense insight into human health, John P. Wise Sr. tells Adverse Reactions co-hosts Anne Chappelle and David Faulkner. Dr. Wise also discusses research on chromosome instability and how you can help people everywhere make connections to the importance of environmental health. About the Guest John P. Wise Sr., PhD, is head of the Wise Laboratory of Environmental and Genetic Toxicology and Professor of...
Space, the Final Risk Assessment Frontier
March 10, 2022 13:00 - 35 minutes - 24.2 MBHow do you set exposure limits to protect human health in a closed container floating in space? Valerie Ryder, a toxicologist at the NASA Johnson Space Center, takes co-hosts Anne Chappelle and David Faulkner into the small world of space toxicologists, where they also discuss research involving lunar dust, bone loss, and CO2. About the Guest Valerie Ryder, PhD, DABT, is a board-certified toxicologist with the NASA Johnson Space Center. She received a BA in chemistry with a minor in microbi...
To Breathe a Little Easier and Why the Lungs Are the Sexiest Organ
June 03, 2021 12:00 - 26 minutes - 18.4 MBFrom vaping to wildfire smoke to pollutants such as diesel exhaust to airborne diseases, the lungs are the organ most exposed to our external environment, according to Ilona Jaspers of the University of North Carolina at Chapel Hill. Dr. Jaspers also introduces co-hosts Anne Chappelle and David Faulkner to convergence science, a new approach to interdisciplinary work meant to bring disparate experts together. About the Guest Ilona Jaspers, PhD, is a Professor at the University of North ...
All the Tox That's Fit to Print . . . or Present . . . or Blog
May 27, 2021 12:00 - 19 minutes - 13.4 MBWith pre-print services, data sharing, open access, and the internet rapidly changing the journal publication landscape, Toxicological Sciences Editor-in-Chief Jeffrey M. Peters provides co-hosts Anne Chappelle and David Faulkner with perspective on how journals are adapting to the times. Dr. Peters also details how new training and guidance programs at ToxSci are aiming to enhance submissions and peer reviews. About the Guest Jeffrey M. Peters, PhD, is a Distinguished Professor of mole...
More Than a Color Scheme: The Future of Toxicology in Green Chemistry
May 20, 2021 12:00 - 24 minutes - 16.6 MBMargaret “Meg” H. Whittaker, Managing Director and Chief Toxicologist of ToxServices LLC, outlines the similarities and differences between risk assessment, alternative assessments, and green chemistry. Co-hosts Anne Chappelle and David Faulkner also discover how alternative assessments can lead to safer and more sustainable products that protect animal, human, and environmental health and the importance of diversifying your portfolio when you’re a student or early career researcher. Abo...
Speak Softly and Carry a Big Dataset: The Exposome
May 13, 2021 12:00 - 27 minutes - 18.7 MBOhio State University’s Darryl B. Hood reveals how a database with about 25,000 environmental factors and variables associated with the public health exposome may soon lead to major breakthroughs in addressing disparate public health outcomes in various communities. He also shares with co-hosts Anne Chappelle and David Faulkner his experiences from a lifetime of firsts—from being a plaintiff in Brown v. Board of Education to transitioning from an HBCU (historically black college and universi...
DNA Isn't Destiny, So What Is?
May 06, 2021 12:00 - 30 minutes - 20.9 MBEpigenetics expert Dana C. Dolinoy of the University of Michigan School of Public Health illuminates how our nascent understanding of the epigenome is leading to breakthroughs in understanding the causes—and potential treatment—of some public health problems. Co-hosts Anne Chappelle and David Faulkner also talk with Dr. Dolinoy about the collaborative science happening in the field and what the future holds for epigenetics. About the Guest Dana C. Dolinoy, PhD, received her PhD in genet...
The United States of Toxicity
April 29, 2021 12:00 - 26 minutes - 18.6 MBRetired National Institute of Environmental Health Sciences (NIEHS) Director and lifelong federal scientist Linda S. Birnbaum discusses the intersection of policy and science, as well as the effect of environmental exposures on public health, with co-hosts Anne Chappelle and David Faulkner. Dr. Birnbaum also shares her insights on how to be an effective leader and the importance of mentorship. About the Guest Linda S. Birnbaum, PhD, DABT, ATS, is the former Director of the National Ins...
Capturing Adverse Reactions
April 22, 2021 15:00 - 9 minutes - 6.25 MBMeet co-hosts Anne Chappelle and David Faulkner as they explore the origins of Adverse Reactions, how people are at the heart of all science, and why the science of toxicology is more relevant than ever. About Anne After graduating from the University of Delaware with a BS in biology in 1991, Anne Chappelle accidentally found her calling when she worked a gap year in an industrial toxicology laboratory. As it turned out, toxicology was the perfect marriage of protecting both human health ...